Combined effects of x irradiation and hyperthermia (42 and 44/sup 0/C) on Chinese hamster V-79 cells in vitro

Journal Article · Sun Jul 01 04:00:00 EDT 1979 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575023· OSTI ID:5686141

Miyakoshi, J ^[1]; Ikebuchi, M; Furukawa, M; Yamagata, K; Sugahara, T; Kano, E

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1. Kyoto Coll. of Pharmacy, Japan

The response to hyperthermia, both alone and in combination with x irradiation, was examined in Chinese hamster V-79 cells in vitro. The effect of hyperthermia in the range from 40 to 45/sup 0/C on cell survival differed markedly at temperatures below 42/sup 0/C and above 43/sup 0/C. Preheating the cells for 2 hr at 42/sup 0/C slightly decreased their sensitivity to the subsequent exposure to 44/sup 0/C, whereas a 15-min exposure to 44/sup 0/C markedly increased the response of the cells to 42/sup 0/C. When cells were exposed to x irradiation in combination with heating at 44/sup 0/C for 15 min and 42/sup 0/C for 60 min, the radioenhancing effect was larger with the 44 ..-->.. 42/sup 0/C sequence than with the 42 ..-->.. 44/sup 0/C sequence, regardless of the position of x irradiation in the sequence of the combined treatments. From these results, it seems that the hyperthermic damage by exposure to 44/sup 0/C may be different from that by exposure to 42/sup 0/C. For the application of hyperthermia to radiotherapy, it is suggested that a short hyperthermic treatment at 44/sup 0/C followed by a long treatment at 42/sup 0/C in combination with x irradiation may be an efficient protocol.

• OSTI ID: 5686141
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 79:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY TEMPERATURE
CELL CULTURES
CELL KILLING
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
GRAPHS
HAMSTERS
HYPERTHERMIA
IN VITRO
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
MAMMALS
MEDICINE
MEDIUM TEMPERATURE
NUCLEAR MEDICINE
NUMERICAL DATA
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RECOVERY
RODENTS
SURVIVAL CURVES
TEMPERATURE DEPENDENCE
TEMPERATURE EFFECTS
THERAPY
TIME DEPENDENCE
VERTEBRATES
X RADIATION