Effects of m-aminobenzamide on the response of Chinese hamster cells to hyperthermia and/or radiation

Journal Article · Sat Jun 01 04:00:00 EDT 1985 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576711· OSTI ID:5517843

Miyakoshi, J; Oda, W; Inagaki, C

The modifying effects of m-aminobenzamide (m-ABA), an inhibitor of poly(ADP-ribose) synthesis, on 42/sup 0/C hyperthermia- and/or radiation-induced cell killing were examined in Chinese hamster V-79 cells. When cells were exposed to 42/sup 0/C hyperthermia in combination with m-ABA (10 mM), cell survival decreased compared with that for 42/sup 0/C hyperthermia alone. Treatments with m-ABA during and/or after X irradiation enhanced radiation-induced cell killing. When cells were exposed to combined treatment with X irradiation, 42/sup 0/C hyperthermia (60 min), and m-ABA (24 hr), cell survival decreased markedly compared with that for X irradiation alone. However, with both X ..-->.. 42/sup 0/C and X ..-->.. 42/sup 0/C ..-->.. m-ABA, the enhancement ratios (ER), designated as D/sub 0/ ratio, were similar. These results suggest that the mechanisms of radiosensitization by m-ABA may be similar to those of 42/sup 0/C hyperthermia.

• Research Organization: Kyoto Pharmaceutical Univ., Japan
• OSTI ID: 5517843
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 102:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560201 -- Thermal Effects-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMIDES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY TEMPERATURE
CELL KILLING
CONNECTIVE TISSUE CELLS
DATA
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
FIBROBLASTS
HAMSTERS
HYPERTHERMIA
INFORMATION
IONIZING RADIATIONS
MAMMALS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RODENTS
SOMATIC CELLS
TEMPERATURE EFFECTS
VERTEBRATES
X RADIATION