Mammalian cell survival response following irradiation with 4 MeV x rays or accelerated helium ions combined with hyperthermia

Journal Article · Tue Jun 01 04:00:00 EDT 1976 · Radiology; (United States)

OSTI ID:7364226

Gerner, E W; Leith, J T; Boone, M L.M.

The effects of hyperthermia on Chinese hamster ovary cell radioresponse were studied using either 4 MeV x rays or accelerated helium ions. Both pre- and postirradiation hyperthermic doses act to decrease the slope of the x-irradiation survival curve in a temperature-dependent manner, while the extrapolation number does not change appreciably. Pre-irradiation hyperthermic treatment has only a slightly greater dose-modifying effect than similar post-irradiation hyperthermia. For cells irradiated with helium, pre-irradiation at 43/sup 0/C (1 hr.) changes the radiation survival curve slope and also the extrapolation number, implying that hyperthermia may act more readily to enhance lethal x-ray damage than lethal helium damage, while having a similar effect on the accumulation of sublethal damage for both of these radiations.

• Research Organization: Univ. of Arizona Coll. of Medicine, Tucson
• OSTI ID: 7364226
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 119:3; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
HAMSTERS
HEATING
HELIUM IONS
IONIZING RADIATIONS
IRRADIATION
MAMMALS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
SURVIVAL TIME
TEMPERATURE DEPENDENCE
VERTEBRATES
X RADIATION