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Opposite effects of WR-2721 and WR-1065 on radiation-induced hypothermia: possible correlation with oxygen uptake

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3577222· OSTI ID:7138678
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Ionizing radiation induces hypothermia in guinea pigs. While systemic injection of the radioprotectant S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR-2721) did not block hyperthermia induced by exposure to 10 Gy of gamma radiation, central administration did attenuate it. The dephosphorylated metabolite of WR-2721, N-(2-mercaptoethyl)-1,3-diaminopropane (WR-1065), accentuated radiation-induced hypothermia by both routes of administration. In brain homogenates, oxygen uptake was inhibited by WR-2721 but elevated by WR-1065. These results suggest that the antagonism of radiation-induced hypothermia found only after central administration of WR-2721 is due to its direct actions and not to its dephosphorylated metabolite and that this effect may be correlated with the inhibition by WR-2721 of oxygen uptake.
Research Organization:
Armed Forces Radiobiology Research Institute, Bethesda, MD (USA)
OSTI ID:
7138678
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 114:2; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY
BODY TEMPERATURE
BRAIN
CENTRAL NERVOUS SYSTEM
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
GAMMA RADIATION
GUINEA PIGS
HYPOTHERMIA
IONIZING RADIATIONS
MAMMALS
NERVOUS SYSTEM
NONMETALS
ORGANS
OXYGEN
RADIATIONS
RADIOINDUCTION
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RODENTS
UPTAKE
VERTEBRATES