Opposite effects of WR-2721 and WR-1065 on radiation-induced hypothermia: possible correlation with oxygen uptake. Scientific report
Technical Report
·
OSTI ID:6068116
Ionizing radiation induces hypothermia in guinea pigs. While systemic injection of the radioprotectant S-2-(3-aminopropylamimo)ethylphosphorothioic acid (WR-2721) did not block hypothermia induced by exposure to 10 Gy of gamma radiation, central administration did attenuate it. The dephosphorylated metabolite of WR-2721, N-(2-mercaptoethyl)-1,3-diaminopropane (WR-1065), accentuated radiation-induced hypothermia by both routes of administration. In brain homogenates, oxygen uptake was inhibited by WR-2721 but elevated by WR-1065. These results suggest that the antagonism of radiation-induced hypothermia found only after central administration of WR-2721 is due to its direct actions and not in its dephosphorylated metabolite, and that this effect may be correlated with the inhibition by WR-2721 of oxygen uptake.
- Research Organization:
- Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
- OSTI ID:
- 6068116
- Report Number(s):
- AD-A-200645/0/XAB; AFRRI-SR-88-15
- Country of Publication:
- United States
- Language:
- English
Similar Records
Opposite effects of WR-2721 and WR-1065 on radiation-induced hypothermia: possible correlation with oxygen uptake
Comparative study of the radioprotective effects of cysteamine, WR-2721, and WR-1065 in cultured human cells. [Reproductive death of cells following. gamma. irradiation used as indicator]
Pharmacokinetics of WR-1065 in mouse tissue following treatment with WR-2721
Journal Article
·
Sun May 01 00:00:00 EDT 1988
· Radiat. Res.; (United States)
·
OSTI ID:7138678
Comparative study of the radioprotective effects of cysteamine, WR-2721, and WR-1065 in cultured human cells. [Reproductive death of cells following. gamma. irradiation used as indicator]
Journal Article
·
Wed Jan 31 23:00:00 EST 1979
· Radiat. Res.; (United States)
·
OSTI ID:6312192
Pharmacokinetics of WR-1065 in mouse tissue following treatment with WR-2721
Journal Article
·
Sat Sep 01 00:00:00 EDT 1984
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:6109798
Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY TEMPERATURE
BRAIN
CENTRAL NERVOUS SYSTEM
COMPARATIVE EVALUATIONS
DOSES
DRUGS
GUINEA PIGS
HYPOTHERMIA
INHIBITION
INJECTION
INTAKE
IONIZING RADIATIONS
MAMMALS
METABOLITES
NERVOUS SYSTEM
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RODENTS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY TEMPERATURE
BRAIN
CENTRAL NERVOUS SYSTEM
COMPARATIVE EVALUATIONS
DOSES
DRUGS
GUINEA PIGS
HYPOTHERMIA
INHIBITION
INJECTION
INTAKE
IONIZING RADIATIONS
MAMMALS
METABOLITES
NERVOUS SYSTEM
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RODENTS
VERTEBRATES