Opposite effects of WR-2721 and WR-1065 on radiation-induced hypothermia: possible correlation with oxygen uptake. Scientific report
Ionizing radiation induces hypothermia in guinea pigs. While systemic injection of the radioprotectant S-2-(3-aminopropylamimo)ethylphosphorothioic acid (WR-2721) did not block hypothermia induced by exposure to 10 Gy of gamma radiation, central administration did attenuate it. The dephosphorylated metabolite of WR-2721, N-(2-mercaptoethyl)-1,3-diaminopropane (WR-1065), accentuated radiation-induced hypothermia by both routes of administration. In brain homogenates, oxygen uptake was inhibited by WR-2721 but elevated by WR-1065. These results suggest that the antagonism of radiation-induced hypothermia found only after central administration of WR-2721 is due to its direct actions and not in its dephosphorylated metabolite, and that this effect may be correlated with the inhibition by WR-2721 of oxygen uptake.
- Research Organization:
- Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
- OSTI ID:
- 6068116
- Report Number(s):
- AD-A-200645/0/XAB; AFRRI-SR-88-15
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY TEMPERATURE
BRAIN
CENTRAL NERVOUS SYSTEM
COMPARATIVE EVALUATIONS
DOSES
DRUGS
GUINEA PIGS
HYPOTHERMIA
INHIBITION
INJECTION
INTAKE
IONIZING RADIATIONS
MAMMALS
METABOLITES
NERVOUS SYSTEM
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RODENTS
VERTEBRATES