Magnetic resonance imaging of transfusional hemosiderosis complicating thalassemia major

Conference · Thu Mar 01 00:00:00 EST 1984 · Radiology; (United States)

OSTI ID:7134266

Brasch, R C; Wesbey, G E; Gooding, C A; Koerper, M A

Tissue deposits of hemosiderin, a paramagnetic iron-protein complex, resulted in marked abnormalities of magnetic resonance (MR) spin-echo signal intensity within the viscera of three children with transfusional hemosiderosis and thalassemia major. In all patients the liver and bone marrow demonstrated abnormally low spin-echo intensities and the kidneys and muscles had abnormally high intensities. These observations correlate with in vitro MR observation of ferric (Fe/sup +3/) solutions, in which concentrations of ferric salts greater than 20 mmol yielded higher intensities than did water alone. MR imaging is sensitive to the tissue deposition of hemosiderin, and MR intensity appears to provide a rough measure of the amount of iron deposited.

• Research Organization: Univ. of California, San Francisco
• OSTI ID: 7134266
• Journal Information: Radiology; (United States), Vol. 150:3; Conference: 68. scientific assembly and annual meeting of the Radiological Society of North America, Chicago, IL, USA, 28 Nov 1982
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
CHILDREN
NUCLEAR MAGNETIC RESONANCE
HEMOSIDERIN
TISSUE DISTRIBUTION
IRON
DEPOSITION
THALASSEMIA
DIAGNOSIS
BONE MARROW
KIDNEYS
LIVER
MUSCLES
RELAXATION TIME
AGE GROUPS
ANEMIAS
ANIMAL TISSUES
BODY
CARBOXYLIC ACIDS
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
ELEMENTS
GLANDS
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
MAGNETIC RESONANCE
METALLOPROTEINS
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PIGMENTS
PORPHYRINS
PROTEINS
RESONANCE
SYMPTOMS
TISSUES
TRANSITION ELEMENTS
550602* - Medicine- External Radiation in Diagnostics- (1980-)
550900 - Pathology
550500 - Metabolism