Decreased bone uptake of technetium-99m polyphosphate in thalassemia major
Journal Article
·
· J. Nucl. Med.; (United States)
OSTI ID:5422499
Bone scans were performed with Tc-99m stannous polyphosphate on four patients with thalassemia major. Three of the scans show generalized decrease in skeletal uptake of the radiopharmaceutical, associated with renal enlargement and markedly increased renal radioactivity. The skeletal findings are consistent with the known bone abnormalities in thalassemia major, which are secondary to the extensive marrow hyperplasia and include loss of trabeculae and cortical thinning with consequent loss of bone mass. The increased renal uptake is probably due in part to the increased renal excretion (secondary to the poor bone uptake) and in part to the tubular dilatation and renal enlargement associated with thalassemia major. In addition, the presence of excessive amounts of iron in these patients may play a role in both the skeletal and renal findings.
- Research Organization:
- New York Hospital-Cornell Medical Center, NY
- OSTI ID:
- 5422499
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 21:1; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Fri Jan 31 23:00:00 EST 1986
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OSTI ID:7134195
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Conference
·
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· Am. J. Roentgenol., Radium Ther. Nucl. Med., v. 124, no. 4, pp. 577- 582
·
OSTI ID:4173021
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·
Mon Dec 31 23:00:00 EST 1973
· J. Nucl. Med., v. 15, no. 1, pp. 47-49
·
OSTI ID:4346565
Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560171 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEMIAS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
CLEARANCE
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
ELEMENTS
EXCRETION
HEMIC DISEASES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IRON
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
METALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RENAL CLEARANCE
RESPONSE MODIFYING FACTORS
SCINTISCANNING
SKELETON
SYMPTOMS
TECHNETIUM 99
TECHNETIUM ISOTOPES
THALASSEMIA
TRANSITION ELEMENTS
UPTAKE
USES
YEARS LIVING RADIOISOTOPES
560171 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEMIAS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
CLEARANCE
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
ELEMENTS
EXCRETION
HEMIC DISEASES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IRON
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
METALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RENAL CLEARANCE
RESPONSE MODIFYING FACTORS
SCINTISCANNING
SKELETON
SYMPTOMS
TECHNETIUM 99
TECHNETIUM ISOTOPES
THALASSEMIA
TRANSITION ELEMENTS
UPTAKE
USES
YEARS LIVING RADIOISOTOPES