Decreased bone uptake of technetium-99m polyphosphate in thalassemia major
Bone scans were performed with Tc-99m stannous polyphosphate on four patients with thalassemia major. Three of the scans show generalized decrease in skeletal uptake of the radiopharmaceutical, associated with renal enlargement and markedly increased renal radioactivity. The skeletal findings are consistent with the known bone abnormalities in thalassemia major, which are secondary to the extensive marrow hyperplasia and include loss of trabeculae and cortical thinning with consequent loss of bone mass. The increased renal uptake is probably due in part to the increased renal excretion (secondary to the poor bone uptake) and in part to the tubular dilatation and renal enlargement associated with thalassemia major. In addition, the presence of excessive amounts of iron in these patients may play a role in both the skeletal and renal findings.
- Research Organization:
- New York Hospital-Cornell Medical Center, NY
- OSTI ID:
- 5422499
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 21:1
- Country of Publication:
- United States
- Language:
- English
Similar Records
Localization of /sup 99m/Tc polyphosphate in soft tissue malignancies
Enhanced detection of a skeletal lesion with delayed /sup 99m/Tc- polyphosphate bone scanning
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
SKELETON
SCINTISCANNING
TECHNETIUM 99
DIAGNOSTIC USES
THALASSEMIA
DIAGNOSIS
BIOLOGICAL LOCALIZATION
IRON
ISOMERIC NUCLEI
PATIENTS
RADIONUCLIDE KINETICS
RENAL CLEARANCE
RESPONSE MODIFYING FACTORS
UPTAKE
ANEMIAS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CLEARANCE
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
ELEMENTS
EXCRETION
HEMIC DISEASES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
METALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SYMPTOMS
TECHNETIUM ISOTOPES
TRANSITION ELEMENTS
USES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)