Participation of the product of gene dnaG/sup +/ in reparation of gamma-induced damage in Escherichia coli DNA
Journal Article
·
· Dokl. Biol. Sci. (Engl. Transl.); (United States)
OSTI ID:7133160
Procedures for culturing and irradiating Escherichia coli are described. Single strand breaks in the DNA, induced by a 14.5 kR dose of radiation were effectively repaired at 30/sup 0/ but not at 43/sup 0/. A comparison of the rates of restoration of DNA synthesis and reparation of strand breaks indicated that these processes were not related. It is suggested that the dnaG/sup +/ gene product fulfills a reparative function by spontaneously removing the damage in DNA, in addition to participating in replication. The implication of the same enzymes and gene products in DNA reparation indicates that they participate in maintaining the stability of DNA in the intact and radiation-damaged cell. (HLW)
- Research Organization:
- Inst. of Cytology, Leningrad
- OSTI ID:
- 7133160
- Journal Information:
- Dokl. Biol. Sci. (Engl. Transl.); (United States), Journal Name: Dokl. Biol. Sci. (Engl. Transl.); (United States) Vol. 226:1-6; ISSN DKBSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BIOSYNTHESIS
DNA
ELECTROMAGNETIC RADIATION
ESCHERICHIA COLI
GAMMA RADIATION
GENES
IONIZING RADIATIONS
MICROORGANISMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
STRAND BREAKS
SYNTHESIS
TEMPERATURE DEPENDENCE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BIOSYNTHESIS
DNA
ELECTROMAGNETIC RADIATION
ESCHERICHIA COLI
GAMMA RADIATION
GENES
IONIZING RADIATIONS
MICROORGANISMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
STRAND BREAKS
SYNTHESIS
TEMPERATURE DEPENDENCE