Mechanisms of tolerance in murine radiation bone marrow chimeras. II. Absence of nonspecific suppression in mature chimeras

Journal Article · Sat Oct 01 04:00:00 EDT 1983 · Transplantation; (United States)

OSTI ID:7133116

Auchincloss, H Jr; Sachs, D H

Spleen cells from a series of allogeneic bone marrow chimeras were sensitized in vitro with stimulator cells from major histocompatibility complex recombinant strains of mice. The combinations were chosen such that both tolerated (host or donor) and nontolerated (third-party) antigens were present on the same stimulator cells in order to determine whether the tolerated host antigens might elicit nonspecific suppressor mechanisms affecting the cell-mediated lympholysis (CML) response to the nontolerated antigens. No evidence for such nonspecific suppression was obtained in several types of assays. Therefore, if suppressor mechanisms exist that mediate such tolerance in mature allogeneic chimeras then these mechanisms must be highly antigen-specific.

• OSTI ID: 7133116
• Journal Information: Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 36:4; ISSN TRPLA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
ANTIGEN-ANTIBODY REACTIONS
ANTIGENS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
BONE MARROW
CELL CULTURES
CHIMERAS
HEMATOPOIETIC SYSTEM
HOST-CELL REACTIVATION
IMMUNOSUPPRESSION
MAMMALS
MICE
MOSAICISM
ORGANS
RADIATION CHIMERAS
RECOVERY
REPAIR
RODENTS
SPECIFICITY
TISSUES
TOLERANCE
VERTEBRATES