Wound healing in x irradiated mammalian skin
Certain parameters of wound healing were investigated in mouse skin given 950 rads and 3325 rads of x irradiation at various times relative to wounding. Increased inflammation, delayed dermal regeneration, and delayed contraction were noted in all irradiated groups. The activation of surrounding hair follicles, a process that usually accompanies wounding in mouse skin, occurred earlier, over a shorter elapsed time, and over a greater area of skin in animals irradiated prior to wounding than in the controls or in those irradiated and wounded simultaneously. Epidermal mitotic activity in wounds made at the time of irradiation was initially depressed but recovered by the second postoperative day. Wounds in pre-irradiated animals gave an unexpected result. They responded with an immediate burst of mitotic activity without the usual 24-hr lag that was seen in controls. In the pre-irradiated specimens a substantial number of cells appeared to die after dividing.
- Research Organization:
- Rhode Island Coll., Providence
- OSTI ID:
- 7110156
- Journal Information:
- T.I.T. (Tower Int. Technomed. Inst., Inc.) J. Life Sci.; (United States), Journal Name: T.I.T. (Tower Int. Technomed. Inst., Inc.) J. Life Sci.; (United States) Vol. 5:3-4; ISSN TJLSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY
CELL DIVISION
ELECTROMAGNETIC RADIATION
HEALING
INJURIES
IONIZING RADIATIONS
IRRADIATION
LOCAL IRRADIATION
MAMMALS
MICE
MITOSIS
ORGANS
RADIATION EFFECTS
RADIATIONS
RECOVERY
RODENTS
SKIN
TIME DEPENDENCE
VERTEBRATES
WOUNDS
X RADIATION