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Effects of whole-body and partial-body x irradiation upon epidermal mitotic activity during wound healing in mouse skin

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3574662· OSTI ID:7215293
Mitotic activity of normal (unwounded) and wounded skin was measured in the control (nonirradiated) and whole-body or partial-body x-irradiated mouse. Higher mitotic activity in the anterior than in the posterior region of the body was found in both the normal and the wounded skin of the control mouse. Whole-body irradiation (500 R) depressed completely the mitotic activity of normal skin 2 to 4 days after irradiation. In spite of this depression in mitotic activity, a surgical incision made 1 to 3 days after irradiation could induce a burst of proliferation after an inhibition of an initial mitosis increase. When the animals were partially irradiated with 500 R 3 days before wounding, it was shown that mitosis at 24 hr after wounding was inhibited markedly by the local effect of irradiation and that mitosis also could be inhibited diversely by the abscopal effect of irradiation. Because of a close similarity of sequential mitotic patterns between whole-body-irradiated and flapped-skin-only-irradiated groups (direct irradiation), the effect of irradiation upon mitosis was considered to be primarily local. Some discussions were made concerning the possible reasons which made a difference in mitotic patterns between the head-only-irradiated group, the irradiated group including the head and other parts of the body except for the skin flap (abscopal irradiation).
Research Organization:
Misaki Marine Biological Station, Japan
OSTI ID:
7215293
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 69:3; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY
CELL DIVISION
ELECTROMAGNETIC RADIATION
EPIDERMIS
EPITHELIUM
EXTERNAL IRRADIATION
HEALING
INJURIES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
MITOSIS
ORGANS
PARTIAL BODY IRRADIATION
RADIATION EFFECTS
RADIATIONS
RECOVERY
RODENTS
SKIN
TISSUES
VERTEBRATES
WHOLE-BODY IRRADIATION
WOUNDS
X RADIATION