Radiation effect in mouse skin: Dose fractionation and wound healing

Journal Article · Tue May 01 04:00:00 EDT 1990 · International Journal of Radiation Oncology, Biology and Physics; (USA)

DOI:https://doi.org/10.1016/0360-3016(90)90443-N· OSTI ID:7062109

Gorodetsky, R; Mou, X D; Fisher, D R; Taylor, J M; Withers, H R ^[1]

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1. Haddassah Univ. Hospital, Jerusalem (Israel)

Radiation induced dermal injury was measured by the gain in the physical strength of healing wounds in mouse skin. A sigmoid dose response for the inhibition of wound healing 14 days after surgery was found for single doses of X rays. The sparing of dermal damage from fractionation of the X-ray dose was quantified in terms of the alpha/beta ratio in the linear-quadratic (LQ) model, at a wide range of doses per fraction reaching as low as about 1 Gy. The fit and the appropriateness of the LQ model for the skin wound healing assay was examined with the use of the Fe-plot in which inverse total dose is plotted versus dose per fraction for wound strength isoeffects. The alpha/beta ratio of the skin was about 2.5 Gy (95% confidence of less than +/- 1 Gy) and was appropriate over a dose range of 1 Gy to about 8 Gy. The low alpha/beta value is typical for a late responding tissue. This assay, therefore, has the advantage of measuring and forecasting late radiation responses of the dermis within a short time after irradiation.

• OSTI ID: 7062109
• Journal Information: International Journal of Radiation Oncology, Biology and Physics; (USA), Journal Name: International Journal of Radiation Oncology, Biology and Physics; (USA) Vol. 18:5; ISSN 0360-3016; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
FRACTIONATED IRRADIATION
HEALING
INJURIES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
ORGANS
RADIATION EFFECTS
RADIATIONS
RECOVERY
RODENTS
SKIN
VERTEBRATES
WOUNDS
X RADIATION