Suppression of natural killer cell activity with radioactive strontium: effector cells are marrow dependent. [Mice, /sup 89/Sr]
Journal Article
·
· J. Immunol.; (United States)
OSTI ID:7110105
NK cells with lytic capacity for Moloney leukemia virus-induced lymphomas have previously been found to occur spontaneously in spleens from nonimmune adult mice. Here, /sup 89/Sr-treatment is shown to suppress NK cell function in adult mice without similarly affecting other cell-mediated immune reactions. Thus, selective /sup 89/Sr-sensitivity distinguishes NK cells from other killer cell types. The present results indicate that in vivo a functional bone marrow is needed for generation and maintenance of NK activity.
- Research Organization:
- Uppsala Univ.
- OSTI ID:
- 7110105
- Journal Information:
- J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 118:4; ISSN JOIMA
- Country of Publication:
- United States
- Language:
- English
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Journal Article
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Mon Oct 01 00:00:00 EDT 1979
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Thu Oct 01 00:00:00 EDT 1981
· J. Immunol.; (United States)
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·
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· Leukemia; (United States)
·
OSTI ID:6729091
Related Subjects
560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
DAYS LIVING RADIOISOTOPES
DISEASES
EVEN-ODD NUCLEI
HEMATOPOIETIC SYSTEM
IMMUNOSUPPRESSION
INTERMEDIATE MASS NUCLEI
ISOTOPES
LYMPHOMAS
MAMMALS
MICE
MICROORGANISMS
NEOPLASMS
NUCLEI
ONCOGENIC VIRUSES
ORGANS
PARASITES
RADIATION EFFECTS
RADIOISOTOPES
RODENTS
STRONTIUM 89
STRONTIUM ISOTOPES
TISSUES
VERTEBRATES
VIRUSES
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
DAYS LIVING RADIOISOTOPES
DISEASES
EVEN-ODD NUCLEI
HEMATOPOIETIC SYSTEM
IMMUNOSUPPRESSION
INTERMEDIATE MASS NUCLEI
ISOTOPES
LYMPHOMAS
MAMMALS
MICE
MICROORGANISMS
NEOPLASMS
NUCLEI
ONCOGENIC VIRUSES
ORGANS
PARASITES
RADIATION EFFECTS
RADIOISOTOPES
RODENTS
STRONTIUM 89
STRONTIUM ISOTOPES
TISSUES
VERTEBRATES
VIRUSES