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Resistance to RadLV-induced leukemia: non-participation of splenic natural killer cells

Journal Article · · Leukemia; (United States)
OSTI ID:6729091
; ; ; ;
The phenotypic expression of genetically determined resistance to radiation leukemia virus (RadLV)-induced leukemia in mice has been shown to reside in the bone marrow. Because the bone marrow contains precursors of natural killer (NK) cells, known to play a role in retrovirally induced infections, and because these cells have been suggested as participating in resistance to radiation-induced leukemia, it was pertinent to establish whether their levels differed in strains of mice susceptible and resistant to leukemia. We therefore tested splenic NK cell levels in C57BL/Ka (susceptible) and B10.A(5R) (resistant) mice before viral inoculation, immediately after viral inoculation, and throughout the preleukemic period and showed that they were not different. This indicates that splenic NK cell levels have no bearing on the resistance to RadLV-induced leukemia and that other immune or non-immune mechanisms must be sought.
Research Organization:
Institut Armand-Frappier, Laval, Quebec (Canada)
OSTI ID:
6729091
Journal Information:
Leukemia; (United States), Journal Name: Leukemia; (United States) Vol. 2:8; ISSN LEUKE
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MATERIALS
BIOLOGICAL VARIABILITY
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CONNECTIVE TISSUE CELLS
DISEASES
FUNCTIONS
GENETIC VARIABILITY
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
IMMUNE SYSTEM DISEASES
LEUKEMIA
LEUKEMIA VIRUSES
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MICROORGANISMS
NEOPLASMS
ONCOGENIC VIRUSES
ORGANS
PARASITES
PHENOTYPE
PRECURSOR
RADIOINDUCTION
RODENTS
SOMATIC CELLS
SPLEEN
TISSUES
TOLERANCE
VERTEBRATES
VIRUSES