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Experimental study on the long-term effect of cadmium in mice fed cadmium-polluted rice with special reference to the effect of repeated reproductive cycles

Journal Article · · Environ. Res.; (United States)
; ; ; ; ; ; ;

Long-term biological effects of cadmium-polluted rice and effect of repeated reproductive cycles on them were examined. Female SLC-B6D2F mice (female C57BL/6, male DBA/2) were fed a rice diet containing 65% unpolished rice for about 2 years from 7 weeks of age. The unpolished rice preparations used were commercially available rice (non-Cd-polluted) and Cd-polluted rice (over 1.0 ppm). Average Cd contents in each diet class were 0.12, 0.48, 1.78, 1.75, and 47.1 ppm (50 ppm Cd as CdCl/sub 2/ added). Some experimental mice were subjected to repeated reproductive cycles (parity group). Hematological, biochemical, and pathological examinations of urine, blood, and tissues, including Cd measurement, were carried out. Results after statistical analysis indicate Cd toxicities such as anemia and disturbances of Ca metabolism. These Cd effects were found to be enhanced by the reproductive cycles. Soft X-ray radiograms showed osteoporosis in the parity groups, especially in the groups with diets of higher Cd content. However, we could not find any sign of disturbance of renal function under our experimental conditions.

Research Organization:
Toyama Medical and Pharmaceutical Univ., Japan
OSTI ID:
7107941
Journal Information:
Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 40:1; ISSN ENVRA
Country of Publication:
United States
Language:
English

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Related Subjects

550602 -- Medicine-- External Radiation in Diagnostics-- (1980-)
560300* -- Chemicals Metabolism & Toxicology
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
ANEMIAS
ANIMALS
BODY
CADMIUM
CALCIUM
CEREALS
CONTAMINATION
DIAGNOSIS
DIET
DISEASES
ELECTROMAGNETIC RADIATION
ELEMENTS
GRASS
HEMIC DISEASES
INGESTION
INTAKE
IONIZING RADIATIONS
MAMMALS
METABOLISM
METALS
MICE
ORGANS
OSTEOPOROSIS
PLANTS
RADIATIONS
REPRODUCTION
RESPONSE MODIFYING FACTORS
RICE
RODENTS
SKELETAL DISEASES
SKELETON
SOFT X RADIATION
SYMPTOMS
TOXICITY
VERTEBRATES
X RADIATION