Effects of cadmium, calcium, age and parity on bone mineral, density and strength in female rats

Thesis/Dissertation · Tue Jan 01 04:00:00 EST 1985

OSTI ID:5884411

Hammond, B F

Weanling female rats were fed diets containing one of three levels of Ca (0.3, 0.6, or 0.9%) and one of four levels of Cd (0, 1, 5, or 10 ppm) in the drinking water. One half of each group was fed first as adolescents (55 days) and the other half as mature (110 days) females. Approximately 10 animals from each group were sacrificed after the first pregnancy and the remaining animals after the fourth pregnancy. Reproductive performance, plasma and bone Ca and P and bone density and strength were measured. After the first pregnancy, offspring of dams treated with 5 or 10 ppm Cd were smaller at birth than offspring of dams treated with 0 or 1 ppm Cd. After the fourth pregnancy, the decreased birth weight was evident only in offspring of dams treated with 10 ppm Cd. Offspring of dams fed 5 or 10 ppm Cd or the 0.3% Ca diet had decreased weaning weight regardless of parity. A 0.3% Ca diet superimposed upon a 5 or 10 ppm Cd intake decreased weaning weight of the male offspring after the first, but not the fourth, pregnancy with the offspring of adolescent dams affected more than those of mature dams. Offspring of dams fed the 0.9% Ca diet did not differ in weaning weight from the offspring of dams fed the 0.6% Ca diet. The 0.3% Ca diet depressed the plasma Ca and the 0.9% Ca diet elevated the plasma Ca and depressed the plasma P when compared to the 0.6% diet.

• Research Organization: Tennessee Univ., Knoxville (USA)
• OSTI ID: 5884411
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ALKALINE EARTH METALS
ANIMAL GROWTH
ANIMALS
BODY
CADMIUM
CALCIUM
DENSITY
DISTRIBUTION
ELEMENTS
FEMALES
GROWTH
INGESTION
INTAKE
MAMMALS
METALS
NONMETALS
ORGANS
PHOSPHORUS
PHYSICAL PROPERTIES
PREGNANCY
RATS
RODENTS
SKELETON
TISSUE DISTRIBUTION
TOXICITY
VERTEBRATES