Effect of potential antidotes on the acute toxicity, tissue disposition and elimination of selenium in rats

Journal Article · Fri Dec 01 04:00:00 EST 1989 · Research Communications in Chemical Pathology and Pharmacology; (USA)

OSTI ID:7104291

Paul, M; Mason, R; Edwards, R ^[1]

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1. Toxicology Research Unit (Medical Research Council of New Zealand), Dunedin (New Zealand)

Treatment of male Wistar rats with sodium selenate (2.24 mg Se/kg, s.c.) inhibited their body weight gain for 24 hr, after which the animals recovered. Intraperitoneal injections of sodium-2,3-dimercaptopropane-1-sulphonic acid (60 mg/kg), meso-2,3-dimercaptosuccinic acid (50.9 mg/kg) and calcium disodium ethylenediamine-tetraacetate (500 mg/kg) 15 min after Se had no protective effect, while 2,3-dimercaptopropanol (15 mg/kg) inhibited the recovery of the Se-treated animal. Sodium diethyldithiocarbamate (DDTC, 70 mg/kg, i.p.) reduced the Se-induced loss of body weight but had no effect on the tissue disposition of {sup 75}Se when injected 15 min, 3 hr or 6 hr after a s.c. injection of sodium ({sup 75}Se) selenite (50 microCi, 17.4 micrograms Se/kg). The citrate salts of bismuth (2.5 and 5 mg Bi/kg, s.c.), antimony (1.5 and 3 mg Sb/kg, s.c.) and germanium (40 mg Ge/kg, s.c.) also reduced the selenate-induced loss of body weight, while germanium citrate (40 mg Ge/kg) and bis-carboxyethyl germanium sesquioxide (80, 200 and 400 mg Ge/kg) promoted significant dose-related increases in the 24 hr urinary excretion of {sup 75}Se when given 15 min after sodium ({sup 75}Se) selenite (30 microCi, 0.5 mg Se/kg, s.c.).

• OSTI ID: 7104291
• Journal Information: Research Communications in Chemical Pathology and Pharmacology; (USA), Journal Name: Research Communications in Chemical Pathology and Pharmacology; (USA) Vol. 66:3; ISSN 0034-5164; ISSN RCOCB
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BEHAVIOR
BETA DECAY RADIOISOTOPES
CHELATING AGENTS
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DOSE-RESPONSE RELATIONSHIPS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAPERITONEAL INJECTION
ISOTOPES
MAMMALS
NUCLEI
RADIOISOTOPES
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SELENIUM
SELENIUM 75
SELENIUM ISOTOPES
SEMIMETALS
TISSUE DISTRIBUTION
TOXICITY
VERTEBRATES
WEIGHT