What are sister chromatid exchanges. [Applications of SCE test in investigations of properties of carcinogens and mutagens]
Conference
·
OSTI ID:7103966
Methods for detecting sister chromatid exchanges (SCEs) and some applications of the SCE test in investigations of the properties of carcinogens and mutagens are discussed. The relations of SCEs to chromosome aberration formation, DNA repair processes, and mutation were studied. It was concluded that SCEs are not simply related to chromosome aberrations or to any one known repair mechanism. They may involve a recombination event, often instituted at the replication fork, but also provoked by any unrepaired damage in the replicated DNA. The molecular mechanism of SCE is unknown and the investigation of the relationship of SCE to mutation is only beginning to yield information.
- Research Organization:
- California Univ., San Francisco, CA (USA). Lab. of Radiobiology
- Sponsoring Organization:
- US Energy Research and Development Administration (ERDA)
- DOE Contract Number:
- EY-76-C-03-1012
- OSTI ID:
- 7103966
- Report Number(s):
- CONF-770551-2
- Country of Publication:
- United States
- Language:
- English
Similar Records
Sister chromatid exchange: the most sensitive mammalian system for determining the effects of mutagenic carcinogens
Segregation of DNA polynucleotide strands into sister chromatids and the use of endoreduplicated cells to track sister chromatid exchanges induced by crosslinks, alkylations, or x-ray damage
Repair replication and sister chromatid exchanges as indicators of excisable and nonexcisable damage in human (xeroderma pigmentosum) cells
Conference
·
Fri Dec 31 23:00:00 EST 1976
·
OSTI ID:7312035
Segregation of DNA polynucleotide strands into sister chromatids and the use of endoreduplicated cells to track sister chromatid exchanges induced by crosslinks, alkylations, or x-ray damage
Journal Article
·
Tue Jun 11 00:00:00 EDT 1996
· Proceedings of the National Academy of Sciences of the United States of America
·
OSTI ID:457013
Repair replication and sister chromatid exchanges as indicators of excisable and nonexcisable damage in human (xeroderma pigmentosum) cells
Journal Article
·
Fri Jul 01 00:00:00 EDT 1977
· J. Toxicol. Environ. Health; (United States)
·
OSTI ID:5088703
Related Subjects
550300 -- Cytology
550400* -- Genetics
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CARCINOGENS
CHROMATIDS
CHROMOSOMAL ABERRATIONS
DNA
DNA REPLICATION
KINETICS
MOLECULAR BIOLOGY
MUTAGENS
MUTATION FREQUENCY
MUTATIONS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
REACTION KINETICS
RECOVERY
REPAIR
STRAND BREAKS
550400* -- Genetics
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CARCINOGENS
CHROMATIDS
CHROMOSOMAL ABERRATIONS
DNA
DNA REPLICATION
KINETICS
MOLECULAR BIOLOGY
MUTAGENS
MUTATION FREQUENCY
MUTATIONS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
REACTION KINETICS
RECOVERY
REPAIR
STRAND BREAKS