Coronary hemodynamic responses during local hemodilution in canine hearts

Journal Article · Tue Mar 01 04:00:00 EST 1988 · American Journal of Physiology; (USA)

OSTI ID:7099294

Crystal, G J ^[1]

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1. Illinois Masonic Medical Center, Chicago (USA)

To evaluate the effect of hemodilution per se on coronary hemodynamics, experiments were performed in 36 anesthetized, open-chest dogs whose left anterior descending coronary artery (LAD) was perfused selectively with either normal arterial blood or arterial blood diluted with lactated Ringer solution. LAD blood flow (CBF) was measured with an electromagnetic flowmeter and its transmural distribution assessed with 15-{mu}m radioactive microspheres. With perfusion pressure normal, graded hemodilution caused progressive, transmurally uniform increases in CBF that showed an nonlinear relationship to inflow hematocrit. Increased peak reactive hyperemic flow and decreased dilator reserve ratio indicated that both reduced viscosity and vasodilation contributed to increased CBF during hemodilution. Hypotension alone reduced CBF, with greater effect in the subendocardium. Additional hemodilution returned CBF to normotensive value, but relative subendocardial hypoperfusion persisted. The present study provides fundamental information on effects of hemodilution on coronary hemodynamics without the systemic responses that complicated previous studies utilizing whole body exchange transfusions.

• OSTI ID: 7099294
• Journal Information: American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 254:3; ISSN 0002-9513; ISSN AJPHA
• Country of Publication: United States
• Language: English

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551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH ISOTOPES
ANIMAL TISSUES
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD CIRCULATION
BLOOD FLOW
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
CERIUM 141
CERIUM ISOTOPES
CHROMIUM 51
CHROMIUM ISOTOPES
CORONARIES
DAYS LIVING RADIOISOTOPES
DIAGRAMS
DOGS
ELECTROCARDIOGRAMS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNGS
MAMMALS
MEDICINE
MICROSPHERES
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIUM
NONMETALS
NUCLEI
ODD-ODD NUCLEI
ORGANS
OXYGEN
PERFUSED TISSUES
PHYSIOLOGY
RADIOASSAY
RADIOISOTOPES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RESPIRATORY SYSTEM
SCANDIUM 46
SCANDIUM ISOTOPES
SECONDS LIVING RADIOISO
STRONTIUM 85
STRONTIUM ISOTOPES
SURGERY
TIN 113
TIN ISOTOPES
TISSUES
VASODILATION
VERTEBRATES