Endothelial-dependent vasodilators preferentially increase subendocardial blood flow

Conference · Wed Mar 05 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:6991139

Pelc, L R; Gross, G J; Warltier, D C

Interference with arachidonic acid metabolism on the effect of acetylcholine (Ach) or arachidonic acid (AA) to preferentially increase subendocardial perfusion was investigated in anesthetized dogs. Hemodynamics, regional myocardial blood flow (MBF (ml/min/g):radioactive microspheres) and the left ventricular transmural distribution of flow (endo/epi) were measured. Intracoronary infusion of Ach (10 ..mu..g/min) and AA (585 ..mu..g/min) significantly (P < .05*) increased myocardial perfusion and selectively redistributed flow to the subendocardium (increased endo/epi) without changes in systemic hemodynamics. Inhibition of phospholipase A/sub 2/ by quinacrine (Q; 600 ..mu..g/min, ic) attenuated the increase in myocardial perfusion produced by Ach but not by AA and inhibited the redistribution of flow to the subendocardium. The present results suggest that endothelium-dependent vasodilators produce a preferential increase in subendocardial perfusion via a product of AA metabolism.

• Research Organization: Medical College of Wisconsin, Milwaukee
• OSTI ID: 6991139
• Report Number(s): CONF-8604222-
• Conference Information: Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:4
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ACETYLCHOLINE
AMINES
AMMONIUM COMPOUNDS
ANIMAL TISSUES
ANIMALS
ARACHIDONIC ACID
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BLOOD FLOW
BODY
CARBOXYLESTERASES
CARBOXYLIC ACIDS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
DOGS
DRUGS
ENDOTHELIUM
ENZYMES
ESTERASES
ESTERS
HEART
HYDROLASES
ISOTOPE APPLICATIONS
ISOTOPES
LIPASE
MAMMALS
METABOLISM
MICROSPHERES
MONOCARBOXYLIC ACIDS
MUSCLES
MYOCARDIUM
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PARASYMPATHOMIMETICS
PERFUSED ORGANS
QUATERNARY COMPOUNDS
RADIOISOTOPES
TISSUES
TRACER TECHNIQUES
VASODILATORS
VERTEBRATES