Enhancement of aryl hydrocarbon hydroxylase activity in cultured rodent cells by x irradiation. [Synergistic effects of benzanthracene]

Journal Article · Mon Feb 26 04:00:00 EST 1979 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(79)90363-1· OSTI ID:7098311

Venkatesan, N ^[1]; Alfred, L J; Torralba, G; Benedict, W F

---

1. Children's Hospital, Los Angeles, CA

X irradiation (5000 rads) was found to enhance the aryl hydrocarbon hydroxylase (AHH)activity of three cell lines. Radiation followed by induction with benz(a)anthracene (5 to 15 micron g/ml) produced a synergistic effect on AHH. These effects were highly significant and were observed most dramatically with a hamster tumor cell line, A(T/sub 1/)Cl-3, and to a lesser extent in secondary hamster embryo cells and mouse C3H/10T 1/2 CL8 cells.

• OSTI ID: 7098311
• Journal Information: Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 24:9; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
550300 -- Cytology
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
BENZANTHRACENE
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
COMPARATIVE EVALUATIONS
CONDENSED AROMATICS
DATA
ELECTROMAGNETIC RADIATION
EMBRYONIC CELLS
ENZYME ACTIVITY
ENZYMES
EXPERIMENTAL DATA
HAMSTERS
HYDROCARBONS
HYDROXYLASE
INFORMATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
NUMERICAL DATA
ORGANIC COMPOUNDS
OXIDOREDUCTASES
RADIATION EFFECTS
RADIATIONS
RODENTS
SYNERGISM
TUMOR CELLS
VERTEBRATES
X RADIATION