Effect of the co-carcinogen benzo(e)pyrene on microsome-mediated chemical mutagenesis in Salmonella typhimurium
Journal Article
·
· Environ. Mutagen.; (United States)
OSTI ID:7097339
Chemical agents that possess the ability to alter tumorigenicity of carcinogens (administered at subthreshold dose) constitute a major health hazard. We have employed the Ames Salmonella assay to examine the effect of co-carcinogenic benzo(e)pyrene (B(e)P) on microsome-mediated chemical mutagenesis. B(e)P enhanced the mutagenic activity induced by 2-acetylaminofluorene (2-AAF) and benzo(a)pyrene (B(a)P) in strains TA1538 and TA98. Enhancement was also noted with N-hydroxy-2-AAF (the proximal metabolite of 2-AAF), but not with an ultimate carcinogenic form (N-acetoxy-2-AAF). These results suggest the use of this approach to detect chemical agents that possess the ability to alter the activity of mutagenic or carcinogenic chemicals.
- Research Organization:
- Oak Ridge National Lab., TN
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 7097339
- Journal Information:
- Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 1; ISSN ENMUD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550700 -- Microbiology
560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AROMATICS
BACTERIA
BENZOPYRENE
CARCINOGENS
CELL CONSTITUENTS
CONDENSED AROMATICS
DOSE-RESPONSE RELATIONSHIPS
HYDROCARBONS
METABOLITES
MICROORGANISMS
MICROSOMES
MUTAGEN SCREENING
MUTAGENESIS
ORGANIC COMPOUNDS
ORGANOIDS
PROMOTERS
RESPONSE MODIFYING FACTORS
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING
SENSITIVITY
SYNERGISM
TOXICITY
TUMOR PROMOTERS
560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AROMATICS
BACTERIA
BENZOPYRENE
CARCINOGENS
CELL CONSTITUENTS
CONDENSED AROMATICS
DOSE-RESPONSE RELATIONSHIPS
HYDROCARBONS
METABOLITES
MICROORGANISMS
MICROSOMES
MUTAGEN SCREENING
MUTAGENESIS
ORGANIC COMPOUNDS
ORGANOIDS
PROMOTERS
RESPONSE MODIFYING FACTORS
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING
SENSITIVITY
SYNERGISM
TOXICITY
TUMOR PROMOTERS