Synergistic, additive, and antagonistic mutagenic responses to binary mixtures of benzo(a)pyrene and benzo(e)pyrene as detected by strains TA98 and TA100 in the Salmonella/microsome assay

Journal Article · Thu Jan 01 04:00:00 EST 1981 · Environ. Mutagen.; (United States)

DOI:https://doi.org/10.1002/em.2860030207· OSTI ID:5172550

Hass, B S; Brooks, E E; Schumann, K E; Dornfeld, S S

Binary mixtures of benzo(a)pyrene (B(a)P) and benzo(e)pyrene (B(e)P) produce synergistic mutagenic (comutagenic) responses in Salmonella typhimurium strain TA98 (a frameshift detector). The optimum enhancement (25 X) was found at B(a)P concentration of 0.3 ..mu..g/plate and B(e)P concentration of 1.5 ..mu..g/plate. The response of strain TA100 (mostly a base-substitution detector) is opposite that of TA98, showing antagonism and additivity in similiar concentration ranges.

• Research Organization: Argonne National Lab., IL
• DOE Contract Number: W-31109-ENG-38
• OSTI ID: 5172550
• Journal Information: Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 3; ISSN ENMUD
• Country of Publication: United States
• Language: English

Related Subjects

560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AROMATICS
BACTERIA
BENZOPYRENE
BINARY MIXTURES
BIOLOGICAL EFFECTS
CONDENSED AROMATICS
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
GENETIC EFFECTS
HYDROCARBONS
MICROORGANISMS
MIXTURES
MUTAGEN SCREENING
ORGANIC COMPOUNDS
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING
SYNERGISM