Folate-binding protein and the absorption of folic acid in the small intestine of the suckling rat
Journal Article
·
· Am. J. Clin. Nutr.; (United States)
OSTI ID:7095404
The folate in milk is largely bound to high-affinity folate-binding protein (FBP). With an in vivo intestinal loop technique, we examined the absorption of folic acid bound to FBP (FA-FBP) in the small intestine of the suckling rat. In contrast to unbound folic acid (FA), FA-FBP is absorbed more avidly in the ileum than in the jejunum (p less than 0.025) and its absorption is not inhibited by 1 mmol sulfasalazine/L. Folate-binding activities in the mucosa of the proximal (duodenum and jejunum combined) and distal (ileum) small intestine were also examined and found to be 0.32 and 1.31 pmol/mg protein, respectively (p less than 0.001). A 6-h fast produced a 42% decrease in folate-binding activity in the distal small intestine (p less than 0.01) but did not change activity in the proximal portion. Collectively, these observations suggest that FA-FBP is absorbed by a mechanism that is distinct from that responsible for the absorption of FA and that absorption does not require prior dissociation of the vitamin-binding protein complex.
- Research Organization:
- Univ. of Chicago, IL (USA)
- OSTI ID:
- 7095404
- Journal Information:
- Am. J. Clin. Nutr.; (United States), Journal Name: Am. J. Clin. Nutr.; (United States) Vol. 48:3; ISSN AJCNA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ABSORPTION
AMINO ACIDS
ANIMALS
AROMATICS
AZAARENES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CHEMICAL BONDS
DIGESTIVE SYSTEM
DRUGS
FOLIC ACID
FOOD
GASTROINTESTINAL TRACT
HEMATINICS
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INTESTINAL ABSORPTION
INTESTINES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LACTATION
MAMMALS
MATERIALS
MILK
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PROTEINS
PTERIDINES
RATS
RODENTS
SMALL INTESTINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES
VITAMIN B GROUP
VITAMINS
59 BASIC BIOLOGICAL SCIENCES
ABSORPTION
AMINO ACIDS
ANIMALS
AROMATICS
AZAARENES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CHEMICAL BONDS
DIGESTIVE SYSTEM
DRUGS
FOLIC ACID
FOOD
GASTROINTESTINAL TRACT
HEMATINICS
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INTESTINAL ABSORPTION
INTESTINES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LACTATION
MAMMALS
MATERIALS
MILK
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PROTEINS
PTERIDINES
RATS
RODENTS
SMALL INTESTINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES
VITAMIN B GROUP
VITAMINS