Correlation between lead retention and intestinal pinocytosis in the suckling mouse
Young animals absorb and retain a greater fraction of an oral dose of lead than do adult animals. It has been proposed that pinocytotic activity in young animals is partially responsible for the increased lead retention and absorption. Radiolabeled lead (5 mg/kg) and polyvinylpyrrolidone (PVP, 50 mg/kg) were administered orally to 12-day-old suckling mice and to adult mice, and the uptake of lead and PVP was determined periodically during a 6-day interval. Intestinal tissue from the distal jejunum and ileum were found to contain the greatest quantities of both lead and PVP. Pretreatment of suckling mice with cortisone acetate resulted in decreased content of lead and PVP within tissue of the intestine, and decreased whole-body lead retention. Cortisone pretreatment produced lower lead concentrations in blood, brain, kidney, and liver. Lead and PVP uptake into intestinal tissue of adult mice was much less than uptake in suckling pups. Cortisone pretreatment of adult mice had no effect on whole-body lead retention or intestinal tissue content of lead or PVP.
- Research Organization:
- Univ. of Rochester, NY
- OSTI ID:
- 6482097
- Journal Information:
- Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 239; ISSN AJPHA
- Country of Publication:
- United States
- Language:
- English
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560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETATES
ADRENAL HORMONES
ADULTS
AGE GROUPS
ALPHA DECAY RADIOISOTOPES
AMIDES
ANIMALS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD SUBSTITUTES
BODY
BODY FLUIDS
BRAIN
CARBOXYLIC ACID SALTS
CENTRAL NERVOUS SYSTEM
CORTICOSTEROIDS
CORTISONE
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
EVEN-EVEN NUCLEI
GASTROINTESTINAL TRACT
GLANDS
GLUCOCORTICOIDS
HEAVY NUCLEI
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTESTINES
IODINE 131
IODINE ISOTOPES
ISOTOPES
KETONES
KIDNEYS
LABELLED COMPOUNDS
LACTAMS
LEAD 210
LEAD ISOTOPES
LIVER
MAMMALS
MATERIALS
MICE
NEONATES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC POLYMERS
ORGANS
PHAGOCYTOSIS
POLYMERS
POLYVINYLS
PREGNANES
PVP
PYRROLES
PYRROLIDONES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RETENTION
RODENTS
SMALL INTESTINE
STEROID HORMONES
STEROIDS
TISSUE DISTRIBUTION
VERTEBRATES
YEARS LIVING RADIOISOTOPES