Effect of dose on lead retention and distribution in suckling and adult female mice

Journal Article · Mon Dec 31 23:00:00 EST 1979 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(80)90116-7· OSTI ID:5841243

Keller, C A; Doherty, R A

Single doses of lead (trace to 445 mg/kg) were administered per os to suckling and adult mice. Both groups exhibited dose-independent lead retention when doses of 4 to 445 mg/kg were administered. However, developmental differences in the fraction of initial dose (FID) retained were evident for all doses administered. A much larger FID was retained in both age groups following administration of carrier-free /sup 203/Pb. The results are consistent with a mechanism of gastrointestinal lead absorption comprising two or more processes. Developmental differences were also observed in organ lead concentration relative to whole body concentration for kidneys, skull and brain 6 days following lead administration. Lead retentions (relative to whole body retention) in brain and in bone were linearly related to dose of lead administered in both suckling and adult age groups. Though uptake of lead into brain and into femur was observed to be directly related to dose over a wide range, relative blood lead concentrations were not linearly correlated with dose administered. The relationships between lead concentrations of blood and organ(s) were also shown to be nonlinear relative to dose. However, blood lead concentration was found to be a reliable indicator of kidney and liver lead concentrations following an acute lead exposure.

• Research Organization: Univ. of Rochester, NY
• OSTI ID: 5841243
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 52; ISSN TXAPA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ADULTS
AGE DEPENDENCE
AGE GROUPS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
FEMALES
FUNCTIONS
GLANDS
HEAVY NUCLEI
INTESTINAL ABSORPTION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
KINETICS
LEAD
LEAD 203
LEAD ISOTOPES
LIVER
MAMMALS
MATERIALS
METABOLISM
METALS
MICE
NEONATES
NERVOUS SYSTEM
NUCLEI
ORGANS
RADIOISOTOPES
REACTION KINETICS
RETENTION FUNCTIONS
RODENTS
SECONDS LIVING RADIOISOTOPES
SKELETON
UPTAKE
VERTEBRATES