Kinetic analysis of technetium-99m d,1-HM-PAO decomposition in aqueous media

Journal Article · Thu Sep 01 04:00:00 EDT 1988 · J. Nucl. Med.; (United States)

OSTI ID:7095013

Hung, J C; Corlija, M; Volkert, W A; Holmes, R A

Technetium-99m-d,1-hexamethylpropyleneamine oxime (/sup 99m/Tc)d,1-HM-PAO) is a neutral-lipophilic chelate formed from a kit in high yield by stannous reduction of Na/sup 99m/TcO/sup 4 -/. Of three methods used to analyze the purity of the /sup 99m/Tc complexes, a single strip method using ether as the developing solvent was the most rapid and simple to perform. The lipophilic chelate converts to /sup 99m/TcO/sup 4 -/ and other hydrophilic products with time and this limits the useful lifetime of the preparations. The rate of decomposition of (/sup 99m/Tc)d,1-HM-PAO increased in the presence of excess stannous ion and at pH greater than 9.

• Research Organization: Univ. of Missouri-Columbia (USA)
• OSTI ID: 7095013
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 29:9; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHEMICAL ANALYSIS
CHEMICAL REACTIONS
COMPLEXES
DECOMPOSITION
DRUGS
HOURS LIVING RADIOISOTOPES
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANOMETALLIC COMPOUNDS
OXIMES
OXYGEN COMPOUNDS
RADIOISOTOPES
RADIOPHARMACEUTICALS
TECHNETIUM 99
TECHNETIUM ISOTOPES
WATER
YEARS LIVING RADIOISOTOPES