Dynamic SPECT with technetium-99m HM-PAO in meningiomas--a comparison with iodine-123 IMP

Journal Article · Thu Jun 01 00:00:00 EDT 1989 · J. Nucl. Med.; (United States)

OSTI ID:5700868

Nakano, S; Kinoshita, K; Jinnouchi, S; Hoshi, H; Watanabe, K

Technetium-99m hexamethylpropyleneamine oxime ((/sup 99m/Tc)HM-PAO) has recently been introduced as an alternative to N-isopropyl-p-/sup 123/I-iodoamphetamine ((/sup 123/I)IMP) for measurement of regional cerebral blood flow. This study compares dynamic SPECT studies using the two tracers in seven patients with meningiomas. Regions of interest were placed over the lesion and contralateral homologous presumed normal area. The counting-rate ratio for the lesion to the contralateral homologous area (L/N ratio) was then calculated in the first image. L/N ratios of ((/sup 99m/Tc)HM-PAO) single photon emission computed tomography (SPECT) were lower than those of ((/sup 123/I)IMP) SPECT, particularly in hypervascular meningiomas. Furthermore, time-activity curves showed that the washout of ((/sup 99m/Tc)HM-PAO) in the tumors was very slow or incomplete, preventing an accurate assessment of vascularity of meningiomas with ((/sup 99m/Tc)HM-PAO), as is generally possible with ((/sup 123/I)IMP).

• Research Organization: Miyazaki Medical College (Japan)
• OSTI ID: 5700868
• Journal Information: J. Nucl. Med.; (United States), Vol. 30:6
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
MENINGES
NEOPLASMS
DIAGNOSIS
RADIOPHARMACEUTICALS
COMPARATIVE EVALUATIONS
AMPHETAMINES
IODINE 123
ISOMERIC NUCLEI
ORGANOMETALLIC COMPOUNDS
OXIMES
PATIENTS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TECHNETIUM 99
AMINES
ANALEPTICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CENTRAL NERVOUS SYSTEM AGENTS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MEMBRANES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIOISOTOPES
SYMPATHOMIMETICS
TECHNETIUM ISOTOPES
TOMOGRAPHY
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics