Dynamic SPECT with iodine-123 IMP in meningiomas

Journal Article · Sat Oct 01 04:00:00 EDT 1988 · J. Nucl. Med.; (United States)

OSTI ID:6558238

Nakano, S; Kinoshita, K; Jinnouchi, S; Hoshi, H; Watanabe, K

Dynamic studies of single photon emission computed tomography (SPECT) were performed with intravenous administration of N-isopropyl-p-(/sup 123/I)iodoamphetamine ((/sup 123/I)IMP) in 12 patients with meningiomas. Their vascularities were also assessed by angiography. Regions of interest (ROIs) were placed over the lesion and the contralateral presumed normal area, the symmetrical one if possible. Time-activity curves (TACs) were then constructed and the counting-rate ratio for the lesion to the contralateral presumed normal area (L/N ratio) was calculated in the first image of the dynamic SPECT. TACs were classified into three types: type I, an initial high uptake and rapid washout type, type II, an initial high uptake and slow washout one, and type III, an initial low uptake one. L/N ratios of angioblastic meningiomas were over 300%, while those of many fibroblastic ones were under 100%, at most 105%. We compared L/N ratios with angiographic vascularities and histologic types and conclude that dynamic SPECT with (/sup 123/I)IMP is the examination of choice for evaluating the vascularity of lesions.

• Research Organization: Miyazaki Medical College (Japan)
• OSTI ID: 6558238
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 29:10; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMPHETAMINES
ANALEPTICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BIOMEDICAL RADIOGRAPHY
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
EFFICIENCY
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOTOPES
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIOISOTOPES
RADIOLOGY
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
SYMPATHOMIMETICS
TOMOGRAPHY