Filling out phenomenon with technetium-99m HM-PAO brain SPECT at the site of mild cerebral ischemia
Although the distribution of (/sup 99m/Tc)hexamethylpropyleneamine oxime (HM-PAO) in the brain is said to be in a flow-related manner without temporal change, we present cases with leakage of (/sup 99m/Tc)HM-PAO (filling out phenomenon) in the delayed image of brain single photon emission computed tomography (SPECT) and clarify its clinical significance. The filling out phenomenon was observed in seven out of 21 cases of cerebrovascular disease and four cases of arteriovenous malformation. The leakage of (/sup 99m/Tc)HM-PAO was also confirmed by visual and semiquantitative analysis. In the pharmacokinetics of (/sup 99m/Tc)HM-PAO in the blood, the percent dose of plasma fraction at 4 hr was reduced to 54% of activity at 30 min. The percent dose of brain blood could be predicted as 3.36%/1 at 30 min and 2.35%/1 at 4 hr after correction with the hematocrit of the brain. The filling out phenomenon of (/sup 99m/Tc)HM-PAO was attributed to a significant reduction of blood activity of (/sup 99m/Tc)HM-PAO in the plasma. Since the initial image might mask reduced rCBF with an increase of rCBV, the late image would have an advantage in accurately evaluating rCBF from the clearance of (/sup 99m/Tc) HM-PAO bound to the plasma. Therefore, the filling out phenomenon of (/sup 99m/Tc)HM-PAO in late images of brain SPECT could show the area of mild cerebral ischemia accompanying cerebral vascular reserve.
- Research Organization:
- National Cardiovascular Center, Osaka (Japan)
- OSTI ID:
- 6028987
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 30:5; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BRAIN
CARDIOVASCULAR DISEASES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISCHEMIA
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANOMETALLIC COMPOUNDS
ORGANS
OXIMES
RADIOISOTOPES
SCINTILLATION COUNTING
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TECHNETIUM 99
TECHNETIUM ISOTOPES
TOMOGRAPHY
VASCULAR DISEASES
YEARS LIVING RADIOISOTOPES