Significance of different dehydrogenase components to radiation-induced impairment of the pentose phosphate cycle. [X radiation, rats]
Journal Article
·
· Radiobiology (USSR) (Engl. Transl.); (United States)
OSTI ID:7094304
Studies on dehydrogenases from erythrocytes and bone marrow of x-irradiated rats indicated that there are negligible phases of change in apoenzyme activity in erythrocytes of irradiated animals, and apparently this was not the cause of lower activity at the early PPC stage, observed in whole erythrocytes with use of the manometric method. We had to assume that the decreased dehydrogenase activity was due to a decrease in NADP concentration due, in particular, to activation of pyridine nucleotidases which, as we know, are localized in the erythrocyte stroma and are bound with lipoproteins. A special series of experiments established that the overall activity of PPC dehydrogenases in hemolysates from intact animals, with removed stroma, corresponded to PPC activity in intact erythrocytes, whereas in hemolysates without removal of stroma, oxygen consumption decreased by more than 50%. Analogous results were obtained with hemolysates of erythrocytes taken from irradiated rats. While no changes in dehydrogenase activity were noted in the group of irradiated animals, the hemolysates were free of stroma, in hemolyzed erythrocytes without removal of stroma showed 5-fold decrease in enzyme activity than in hemolysates from nonirradiated animals.
- Research Organization:
- Central Scientific Research Inst. of Roentgenology and Radiology, Leningrad
- OSTI ID:
- 7094304
- Journal Information:
- Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 17:1; ISSN RADBA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CARBOHYDRATES
CHEMISTRY
DEHYDROGENASES
ELECTROMAGNETIC RADIATION
ENZYMES
ERYTHROCYTES
HEMATOPOIETIC SYSTEM
IONIZING RADIATIONS
MAMMALS
METABOLISM
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PENTOSES
PHOSPHATES
PHOSPHORUS COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RATS
RODENTS
SACCHARIDES
TISSUES
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CARBOHYDRATES
CHEMISTRY
DEHYDROGENASES
ELECTROMAGNETIC RADIATION
ENZYMES
ERYTHROCYTES
HEMATOPOIETIC SYSTEM
IONIZING RADIATIONS
MAMMALS
METABOLISM
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PENTOSES
PHOSPHATES
PHOSPHORUS COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RATS
RODENTS
SACCHARIDES
TISSUES
VERTEBRATES
X RADIATION