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The effect of. gamma. irradiation and cystamine on superoxide dismutase activity in the bone marrow and erythocytes of rats. [/sup 60/Co]

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3575888· OSTI ID:6942203
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The effect of a single dose of cystamine (50 mg/kg body wt; ip) on superoxide dismutase activity (E.C. 1.15.1.1; SOD) was studied in the cytosol fraction of bone marrow cells and erythrocytes of peripheral blood. The experiments were carried out on irradiated (8.0 Gy /sup 60/Co) and nonirradiated male Wistar rats. Whole-body irradiation caused a decrease in the specific activity of superoxide dismutase in the bone marrow which persisted for more than 14 days, whereas an increased activity occurred in erythrocytes at the same intervals. Cystamine administration to rats prior to irradiation led to decreased SOD activity in the bone marrow that was less pronounced than in the nonprotected, irradiated animals. In erythrocytes, treatment with cystamine prior to irradiation considerably increased SOD activity (especially on Day 14); this increase was much more pronounced than that after either cystamine administration or irradiation. The administration of cystamine to nonirradiated animals led to a decrease in SOD activity in the bone marrow on the third day only; however, in erythrocytes the activity increased (mostly on Day 14). Irradiation of the bone marrow was reflected in a substantial decrease of its cellularity that was, to a certain extent, normalized after cystamine treatment. The SOD activity per bone marrow cell (expressed in U/10/sup 6/ cells) was increased in the protected rats on the third day after irradiation, but this increase was not as pronounced as in nonprotected, irradiated rats.
Research Organization:
Charles University, Hradec Kralove, Czechoslovakia
OSTI ID:
6942203
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 91:3; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
COBALT 60
COBALT ISOTOPES
CYSTAMINE
DRUGS
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
ENZYMES
ERYTHROCYTES
EXTERNAL IRRADIATION
GAMMA RADIATION
HEMATOPOIETIC SYSTEM
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MINUTES LIVING RADIOISOTOPES
MIXED-FUNCTION OXIDASES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGENASES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
TISSUES
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES