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Radioprotective effects of AET and mexamine on pentose cycle dehydrogenases. [Rats, guinea pigs, x radiation]

Journal Article · · Radiobiology (USSR) (Engl. Transl.); (United States)
OSTI ID:6754571
; ; ;
AET and mexamine were given intraperitoneally to guinea pigs and rats 15 min before whole-body x irradiation. The activity of pentose cycle dehydrogenase was assayed 4 days later in guinea pig erythrocytes and 8 days later in rat erythrocytes. The activity of glucose-6-phosphate dehydrogenase in rat bone marrow was studied 4 to 10 days after irradiation. AET and mexamine prevented depression of pentose cycle dehydrogenase in irradiated guinea pigs. In experiments with rats, mexamine had a more marked radioprotective effect while AET did not have a radioprotective effect. The radioprotective effect of AET and mexamine on glucose-6-phosphate dehydrogenase was also demonstrated in experiments with bone marrow from irradiated rats. (HLW)
Research Organization:
Central Scientific Research Inst. of Roentgenology and Radiology, Leningrad
OSTI ID:
6754571
Journal Information:
Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 17:6; ISSN RADBA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AET
AMINES
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CARBONIC ACID DERIVATIVES
DEHYDROGENASES
DRUGS
ELECTROMAGNETIC RADIATION
ENZYMES
ERYTHROCYTES
ETHERS
GUINEA PIGS
HEMATOPOIETIC SYSTEM
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
IONIZING RADIATIONS
MAMMALS
METABOLISM
MEXAMINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
OXIDOREDUCTASES
PYRROLES
RADIATION EFFECTS
RADIATION PROTECTION
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SEROTONIN
SYMPATHOMIMETICS
THIOUREAS
TISSUES
TRYPTAMINES
VERTEBRATES
X RADIATION