Inhalation developmental toxicology studies: Teratology study of tetrahydrofuran in mice and rats: Final report

Technical Report · Mon Aug 01 04:00:00 EDT 1988

DOI:https://doi.org/10.2172/7090818· OSTI ID:7090818

Mast, T J; Evanoff, J J; Stoney, K H; Westerberg, R B; Rommereim, R L; Weigel, R J

Tetrahydrofuran (THF), a four-carbon cyclic ether, is widely used as an industrial solvent. Although it has been used in large quantities for many years, few long-term toxicology studies, and no reproductive or developmental studies, have been conducted on THF. This study addresses the potential for THF to cause developmental toxicity in rodents by exposing Sprague-Dawley rats and Swiss (CD-1) mice to 0, 600, 1800, or 5000 ppm tetrahydrofuran (THF) vapors, 6 h/day, 7 dy/wk. Each treatment group consisted of 10 virgin females (for comparison), and approx.33 positively mated rats or mice. Positively mated mice were exposed on days 6--17 of gestation (dg), and rats on 6--19 dg. The day of plug or sperm detection was designated as O dg. Body weights were obtained throughout the study period, and uterine and fetal body weights were obtained at sacrifice (rats, 20 dg; mice, 18 dg). Implants were enumerated and their status recorded and live fetuses were examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. 27 refs., 6 figs., 23 tabs.

• Research Organization: Pacific Northwest Lab., Richland, WA (USA)
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 7090818
• Report Number(s): PNL-6685; ON: DE89001383
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
COMPARATIVE EVALUATIONS
CONGENITAL MALFORMATIONS
DOCUMENT TYPES
DOSE-RESPONSE RELATIONSHIPS
FETUSES
FURANS
HETEROCYCLIC COMPOUNDS
INHALATION
INTAKE
LIFE SPAN
LITTER SIZE
MALFORMATIONS
MAMMALS
MATTER
MICE
MORTALITY
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PRENATAL EXPOSURE
PROGRESS REPORT
RATS
RODENTS
SEX DEPENDENCE
TERATOGENESIS
TETRAHYDROFURAN
TIME DEPENDENCE
TOXICITY
VERTEBRATES
VOLATILE MATTER