Inhalation developmental toxicology studies: Gallium arsenide in mice and rats

Technical Report · Sat Dec 01 04:00:00 EST 1990

DOI:https://doi.org/10.2172/6358394· OSTI ID:6358394

Mast, T J; Greenspan, B J; Dill, J A; Stoney, K H; Evanoff, J J; Rommereim, R L

Gallium arsenide is a crystalline compound used extensively in the semiconductor industry. Workers preparing solar cells and gallium arsenide ingots and wafers are potentially at risk from the inhalation of gallium arsenide dust. The potential for gallium arsenide to cause developmental toxicity was assessed in Sprague- Dawley rats and CD-1 (Swiss) mice exposed to 0, 10, 37, or 75 mg/m{sup 3} gallium arsenide, 6 h/day, 7 days/week. Each of the four treatment groups consisted of 10 virgin females (for comparison), and {approx}30 positively mated rats or {approx}24 positively mated mice. Mice were exposed on 4--17 days of gestation (dg), and rats on 4--19 dg. The day of plug or sperm detection was designated as 0 dg. Body weights were obtained throughout the study period, and uterine and fetal body weights were obtained at sacrifice (rats, 20 dg; mice, 18 dg). Implants were enumerated and their status recorded. Live fetuses were sexed and examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. Gallium and arsenic concentrations were determined in the maternal blood and uterine contents of the rats (3/group) at 7, 14, and 20 dg. 37 refs., 11 figs., 30 tabs.

• Research Organization: Pacific Northwest Lab., Richland, WA (USA)
• Sponsoring Organization: DOE/ER; DOHHS
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 6358394
• Report Number(s): PNL-7367; ON: DE91005300; CNN: NIH-Y01-ES-70153
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ARSENIC COMPOUNDS
ARSENIDES
BENCH-SCALE EXPERIMENTS
BIOLOGICAL EFFECTS
COMPILED DATA
DATA
DOCUMENT TYPES
EMBRYOS
EQUIPMENT
FETUSES
GALLIUM ARSENIDES
GALLIUM COMPOUNDS
HUMAN POPULATIONS
INFORMATION
INHALATION
INTAKE
LABORATORY ANIMALS
LABORATORY EQUIPMENT
MAMMALS
MATERIALS
MICE
MORPHOLOGICAL CHANGES
NUMERICAL DATA
OCCUPATIONAL SAFETY
PNICTIDES
POPULATIONS
PROGRESS REPORT
RATS
RODENTS
SAFETY
SCREENING
SEMICONDUCTOR MATERIALS
SENSITIVITY
TERATOGEN SCREENING
TOXICITY
VERTEBRATES