Inhalation developmental toxicology studies: Teratology study of isoprene in mice and rats: Final report

Technical Report · Sun Jan 01 04:00:00 EST 1989

DOI:https://doi.org/10.2172/6211306· OSTI ID:6211306

Mast, T J; Evanoff, J J; Stoney, K H; Westerberg, R B; Rommereim, R L; Weigel, R J

Isoprene, a reactive, branched diene, is used in large quantities in the manufacture of polyisoprene and as a copolymer in the synthesis of butyl rubber. The potential for isoprene to cause developmental toxicity was assessed in rodents, by exposing four groups each of Sprague-Dawley rats and Swiss (CD-1) mice to 0, 280, 1400, or 7000 ppM isoprene vapors, 6 h/day, 7 day/wk. Each treatment group consisted of 10 virgin females (for comparison), and approx.30 positively mated rats or mice. Positively mated mice were exposed on days 6-17 of gestation (dg), and rats on 6-19 dg. The day of plug or sperm detection was designated as 0 dg. Body weights were obtained throughout the study period, and uterine and fetal body weights were obtained at sacrifice (rats, 20 dg; mice, 18 dg). Implants were enumerated and their status recorded. Live fetuses were sexed and examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. 31 refs., 6 figs., 19 tabs.

• Research Organization: Pacific Northwest Lab., Richland, WA (USA)
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 6211306
• Report Number(s): PNL-6829; ON: DE89008095
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
COMPARATIVE EVALUATIONS
DIENES
DOCUMENT TYPES
DOSE-RESPONSE RELATIONSHIPS
HYDROCARBONS
INHALATION
INTAKE
ISOPRENE
LIFE SPAN
LITTER SIZE
MAMMALS
MICE
MORTALITY
ORGANIC COMPOUNDS
POLYENES
PRENATAL EXPOSURE
PROGRESS REPORT
RATS
RODENTS
SEX DEPENDENCE
TERATOGENESIS
TIME DEPENDENCE
TOXICITY
VERTEBRATES