Nonimmunogenic radiation-induced lymphoma: immunity induction by a somatic cell hybrid
Journal Article
·
· J. Natl. Cancer Inst.; (United States)
OSTI ID:7088734
The cell line designated PIR-2 is a nonimmunogenic X-ray-induced thymoma of C57BL/6 origin that is unable to induce antitumor immunity in syngeneic lymphocytes in vitro and in mice in vivo. Fusion of PIR-2 with an allogeneic universal fuser A9HT (clone 3c) resulted in the establishment of a somatic cell hybrid designated A9/PIR. C57BL/6 lymphocytes sensitized in vitro with A9/PIR could lyse parental PIR-2 cells, as well as other syngeneic tumors. However, immunization of mice with the hybrid significantly enhanced PIR-2 tumor takes while it partially protected the animals against a challenge with unrelated syngeneic tumors. The results imply that somatic cell hybridization can increase the immunogenicity of an otherwise nonimmunogenic tumor. However, in view of the enhancing effects of hybrid preimmunization on parental tumor cell growth, the possible application of this approach for immunotherapy is questionable.
- Research Organization:
- The Hebrew University-Hadassah Medical School, Jerusalem, Israel
- OSTI ID:
- 7088734
- Journal Information:
- J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 68:5; ISSN JNCIA
- Country of Publication:
- United States
- Language:
- English
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550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
551000 -- Physiological Systems
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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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ELECTROMAGNETIC RADIATION
HYBRIDIZATION
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IMMUNOTHERAPY
IONIZING RADIATIONS
LEUKOCYTES
LYMPHOCYTES
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SOMATIC CELLS
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551000 -- Physiological Systems
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
HYBRIDIZATION
IMMUNITY
IMMUNOTHERAPY
IONIZING RADIATIONS
LEUKOCYTES
LYMPHOCYTES
LYMPHOMAS
MATERIALS
NEOPLASMS
RADIATIONS
RADIOINDUCTION
SOMATIC CELLS
THERAPY
X RADIATION