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Secretin enhances (/sup 14/C)erythritol clearance in unanesthetized dogs

Journal Article · · Dig. Dis. Sci.; (United States)
DOI:https://doi.org/10.1007/BF01308122· OSTI ID:7086612
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To determine the effect of secretin infusion on clearance of inert markers into bile, unanesthetized dogs fitted with Thomas cannulas received continuous infusions of (/sup 14/C)erythritol and (/sup 3/H)inulin throughout study. Taurocholic acid administered sequentially at 9.0, 20.0, and 40.0 mumol/min enhanced (/sup 14/C)erythritol clearance, and GIH secretin (3 units/min) administered along with TCA (40.0 mumol/min) increased (/sup 14/C)erythritol clearance from 4.9 +/- 1.2 ml/10 min to 6.8 +/- 1.3 ml/10 min (P less than 0.001), but simultaneously measured (/sup 3/H)inulin clearance was unaltered. Secretin alone also increased (/sup 14/C)erythritol clearance but did not alter (/sup 3/H)inulin clearance. The increase in (/sup 14/C)erythritol clearance per unit increase in bile flow was less during secretin infusion than TCA. Thus, secretin increases (/sup 14/C)erythritol transport through restricted channels, probably distal to the canaliculi. (/sup 14/C)Erythritol may not be an accurate marker for canalicular bile flow in dogs during secretin infusion.
Research Organization:
Department of Medicine, The University of Chicago, IL
OSTI ID:
7086612
Journal Information:
Dig. Dis. Sci.; (United States), Journal Name: Dig. Dis. Sci.; (United States) Vol. 27:1; ISSN DDSCD
Country of Publication:
United States
Language:
English

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Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550201 -- Biochemistry-- Tracer Techniques
551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALCOHOLS
ANIMALS
BILE
BILIARY TRACT
BIOLOGICAL MATERIALS
BODY FLUIDS
CARBOHYDRATES
CARBON 14 COMPOUNDS
CLEARANCE
COMPARATIVE EVALUATIONS
DIGESTIVE SYSTEM
DOGS
ERYTHRITOL
HORMONES
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
MEASURING METHODS
MONOSACCHARIDES
ORGANIC COMPOUNDS
PHYSIOLOGY
QUANTITY RATIO
SACCHARIDES
SECRETIN
TRACER TECHNIQUES
TRANSLOCATION
TRITIUM COMPOUNDS
VERTEBRATES