Postnatal development of bile secretory physiology in the dog

Journal Article · Mon Apr 01 04:00:00 EST 1985 · J. Pediatr. Gastroenterol. Nutr.; (United States)

DOI:https://doi.org/10.1097/00005176-198504000-00018· OSTI ID:5125375

Tavoloni, N; Jones, M J; Berk, P D

To determine whether bile formation in the dog is an immature process at birth, several determinants of bile secretion were studied in anesthetized, bile duct-cannulated puppies of 0-42 days of age and adult dogs. Basal canalicular bile flow rate, estimated by /sup 14/C-erythritol biliary clearance, averaged 0.182 microliter/min/g liver in 0-3 day-old puppies and increased to 0.324 and 0.461 microliter/min/g in puppies 7-21 and 28-42 days of age, respectively. Calculated ductular bile water reabsorption (/sup 14/C-erythritol biliary clearance-bile flow) was virtually absent in 0-3 day-old puppies, and averaged 0.017 and 0.092 microliter/min/g in puppies of 7-21 and 28-42 days of age, respectively. In adult dogs, ductular bile water reabsorption was 0.132 microliter/min/g. These functional deficiencies of the newborn dog were associated with an increased biliary permeability to /sup 3/H-inulin which could not be accounted for solely by an increased solute diffusion due to the lower rate of canalicular bile flow. Administration of taurocholate up to 2000 nmol/min/kg produced in all animals a similar increase in canalicular bile flow and bile acid excretion, and was not associated with changes in ductular bile water reabsorption rate. These findings are interpreted to indicate that, in the dog, bile secretory function is immature at birth and develops during postnatal life.

• Research Organization: Polly Annenberg Levee Hematology Center, New York, NY
• OSTI ID: 5125375
• Journal Information: J. Pediatr. Gastroenterol. Nutr.; (United States), Journal Name: J. Pediatr. Gastroenterol. Nutr.; (United States) Vol. 2; ISSN JPGND
• Country of Publication: United States
• Language: English

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551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADULTS
AGE DEPENDENCE
AGE GROUPS
ALCOHOLS
ANIMALS
BILE
BILIARY TRACT
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARBOHYDRATES
CARBON 14 COMPOUNDS
DIGESTIVE SYSTEM
DOGS
ERYTHRITOL
GLANDS
HYDROXY COMPOUNDS
INULIN
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIVER
MAMMALS
MATERIALS
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
PERMEABILITY
PHYSIOLOGY
POLYSACCHARIDES
SACCHARIDES
SECRETION
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES