Production of radiopharmaceuticals for positron emission tomography via laboratory robotics
The production of radiopharmaceuticals used in positron emission tomography (PET) can require large amounts of activity at the start of synthesis in order to yield sufficient labeled material for clinical studies. Several investigators have developed remote and automated systems for the routine production of PET radiopharmaceuticals in order to reduce radiation exposure to personnel. Such devices, however, suffer from limited flexibility and can be relatively complicated in design. These systems are also limited to the production of a single or a few closely related compounds. Furthermore, changes in chemistry would require considerable modifications in hardware and/or software in order to bring the device back into operation. To circumvent the above limitations associated with the remote production of PET radiopharmaceuticals, the authors have investigated the use of laboratory robotics as a flexible alternative to the synthesis of several short-lived radiopharmaceuticals in a single remote hot cell. The purpose of this investigation is to demonstrate how a single laboratory robot can be used to produce several unrelated radiopharmaceuticals for clinical PET imaging with reduced radiation exposure to personnel and minimal set-up time between each different robotic synthesis.
- Research Organization:
- Washington Univ. School of Medicine, Seattle (USA)
- OSTI ID:
- 7086075
- Report Number(s):
- CONF-8711195-
- Journal Information:
- Trans. Am. Nucl. Soc.; (United States), Journal Name: Trans. Am. Nucl. Soc.; (United States) Vol. 55; ISSN TANSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
420203* -- Engineering-- Handling Equipment & Procedures
COMPUTERIZED TOMOGRAPHY
DESIGN
DIAGNOSTIC TECHNIQUES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
LABELLED COMPOUNDS
MATERIALS HANDLING
POSITRON COMPUTED TOMOGRAPHY
PRODUCTION
PROGRAMMING
RADIATION PROTECTION
RADIOPHARMACEUTICALS
ROBOTS
TOMOGRAPHY
USES