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Routine radiopharmaceutical production for positron emission tomography in a clinical setting

Conference · · Trans. Am. Nucl. Soc.; (United States)
OSTI ID:5007394
; ; ;

With the development of positron emission tomography (PET), many cellular processes can now be investigated in humans. To perform this task, positron-emitting radioisotopes, which decay by emission of coincidence photons externally detected after positron annihilation, are used in PET. Thus, biochemically and pharmacologically active compounds can be labeled with cyclotron-produced positron-emitting radioisotopes of carbon, nitrogen, oxygen, and fluorine to probe enzyme reaction rates, membrane transport, metabolism, synthesis processes, and various pharmacological parameters. The development of PET technology for clinical applications requires not only the development of a minicyclotron technology, but also the targetry and reliable synthetic procedures for labeled compounds, all of which must be finally integrated into automated delivery systems. Although an integrated unit (cyclotron, chemistry, imaging device) specially designed for PET in clinical settings has never been developed, the work in progress in this area indicates that its implementation is immediately possible.

Research Organization:
Univ. of California, Los Angeles
OSTI ID:
5007394
Report Number(s):
CONF-851115-
Journal Information:
Trans. Am. Nucl. Soc.; (United States), Journal Name: Trans. Am. Nucl. Soc.; (United States) Vol. 50; ISSN TANSA
Country of Publication:
United States
Language:
English

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Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBON 11
CARBON ISOTOPES
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DOSES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
FLUORINE 18
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
ISOTOPE PRODUCTION
ISOTOPES
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NITROGEN 13
NITROGEN ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
OXYGEN 15
OXYGEN ISOTOPES
POSITRON COMPUTED TOMOGRAPHY
RADIATION DOSES
RADIOISOTOPES
RESEARCH PROGRAMS
TOMOGRAPHY