Cyclotrons and radiopharmaceuticals in positron emission tomography

Journal Article · Thu Mar 10 23:00:00 EST 1988 · JAMA, J. Am. Med. Assoc.; (United States)

OSTI ID:5294921

Positron emission tomography (PET) can prober biochemical pathways in vivo and can provide quantitative data; for that purpose, tracers labeled with positron-emitting radioisotopes are essential. This report describes the tracers that are being used or that may have future use, their production by cyclotrons, and other needed resources for PET imaging. Current routine and automated methods for convenient production of labeled compounds, coupled with simple computer-controlled accelerators, can support the creation of clinical PET centers in any large medical institution, obviating the need for in-depth research teams. An alternate approach involves the development of regional centers that provide in-house service and that supply fluorine 18- and carbon 11- labeled compounds to nearby hospitals with PET machines.

• DOE Contract Number: AC02-76CH00016
• OSTI ID: 5294921
• Journal Information: JAMA, J. Am. Med. Assoc.; (United States), Journal Name: JAMA, J. Am. Med. Assoc.; (United States) Vol. 259:10; ISSN JAMAA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703 -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCELERATORS
ALDEHYDES
AMINES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOCHEMISTRY
CARBOHYDRATES
CARBON 14
CARBON ISOTOPES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CHEMICAL PREPARATION
CHEMICAL PROPERTIES
CHEMISTRY
COMPUTERIZED TOMOGRAPHY
CYCLIC ACCELERATORS
CYCLOTRONS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DOPAMINE
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
FLUORINE 18
FLUORINE ISOTOPES
GLUCOSE
HEXOSES
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
IN VIVO
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MEMBRANE PROTEINS
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
NEUROREGULATORS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
OXYGEN 15
OXYGEN ISOTOPES
PHENOLS
POLYPHENOLS
POSITRON COMPUTED TOMOGRAPHY
PROTEINS
RADIOISOTOPE GENERATORS
RADIOISOTOPES
RADIOPHARMACEUTICALS
RECEPTORS
SACCHARIDES
SYMPATHOMIMETICS
SYNTHESIS
TOMOGRAPHY
USES
YEARS LIVING RADIOISOTOPES