Effect of perfusate hematocrit on urea permeability-surface area in isolated dog lung
Journal Article
·
· J. Appl. Physiol.; (United States)
OSTI ID:7085606
Seven dog lower left lung lobes were statically inflated and perfused at a constant rate for each lobe with a perfusate in which the hematocrit was altered over a wide range. The permeability-surface area of urea was calculated from multiple indicator dilution curves using two separate injectates for each hematocrit level. One injectate contained only /sup 125/I-albumin as the vascular reference tracer and the other contained both /sup 51/Cr-erythrocytes and /sup 125/I-albumin as the vascular reference tracers; both contained (/sup 14/C)urea as the permeating tracer. The results strongly indicate that the phenomenon of erythrocyte trapping of urea does not affect the calculation of urea permeability-surface area product provided the appropriate albumin-erythrocyte composite reference tracer is utilized in its calculation.
- Research Organization:
- Vanderbilt Univ. School of Medicine, Nashville, TN
- OSTI ID:
- 7085606
- Journal Information:
- J. Appl. Physiol.; (United States), Journal Name: J. Appl. Physiol.; (United States) Vol. 4; ISSN JAPYA
- Country of Publication:
- United States
- Language:
- English
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Journal Article
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Thu Jan 31 23:00:00 EST 1985
· J. Appl. Physiol.; (United States)
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OSTI ID:5520656
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Journal Article
·
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· Exp. Lung Res.; (United States)
·
OSTI ID:5742491
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Conference
·
Fri Feb 28 23:00:00 EST 1986
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
·
OSTI ID:5389484
Related Subjects
551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALBUMINS
AMIDES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COUNT
BODY
BODY FLUIDS
CARBON 14 COMPOUNDS
CARBONIC ACID DERIVATIVES
CHROMIUM 51
CHROMIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
DOGS
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
EVEN-ODD NUCLEI
IN VITRO
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LUNGS
MAMMALS
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PERFUSED ORGANS
PERMEABILITY
PROTEINS
RADIOISOTOPES
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
SURFACE AREA
SURFACE PROPERTIES
TRACER TECHNIQUES
UREA
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ALBUMINS
AMIDES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COUNT
BODY
BODY FLUIDS
CARBON 14 COMPOUNDS
CARBONIC ACID DERIVATIVES
CHROMIUM 51
CHROMIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
DOGS
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
EVEN-ODD NUCLEI
IN VITRO
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LUNGS
MAMMALS
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PERFUSED ORGANS
PERMEABILITY
PROTEINS
RADIOISOTOPES
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
SURFACE AREA
SURFACE PROPERTIES
TRACER TECHNIQUES
UREA
VERTEBRATES