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Comparison of sodium and urea as indicators of pulmonary vascular permeability

Journal Article · · Exp. Lung Res.; (United States)
; ;
The objective of this work was to compare the blood-tissue transport properties of /sup 14/C-urea and /sup 24/Na in the lung circulation. The extraction of both substances was measured relative to intravascular reference tracers (/sup 125/I-albumin for /sup 24/Na, /sup 51/Cr red cells and /sup 125/I-albumin for /sup 14/C-urea) in single-pass transpulmonary multiple indicator curves measured in awake sheep. Sheep were studied in baseline condition, after infusion of histamine solution (4 micrograms/kg-min for 4 hr), and after microvascular pressure was elevated. Permeability-surface area was computed for both sodium (PSn) and urea (PSu) by the Crone extraction model and by a mathematical model. In spite of the fact that the free diffusion coefficients of sodium and urea are approximately equal, the mean ratio of Crone PSn/PSu for baseline studies was 0.76. PSu was significantly increased by histamine infusion but PSn was not. The variation in PSn with histamine and increased pressure was marked. Thus, neither manipulation altered the ratio PSn/PSu in a consistent fashion. Correction of PS for extravascular distribution volumes of urea and Na did not change the PS ratio significantly. We concluded that the diffusional resistance to sodium is higher than expected from its diffusivity, possibly because of charge, and that PS for urea is more sensitive to changes in lung vascular permeability.
Research Organization:
Pulmonary Circulation Center, School of Medicine, Nashville, Tennessee
OSTI ID:
5742491
Journal Information:
Exp. Lung Res.; (United States), Journal Name: Exp. Lung Res.; (United States) Vol. 4:2; ISSN EXLRD
Country of Publication:
United States
Language:
English

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Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALI METAL ISOTOPES
ALKALI METALS
AMIDES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CIRCULATION
BODY
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CARBON 14 COMPOUNDS
CARBONIC ACID DERIVATIVES
CHROMIUM 51
CHROMIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPE DILUTION
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
LUNGS
MATERIALS
MEMBRANE TRANSPORT
METALS
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PERMEABILITY
RADIOISOTOPES
RESPIRATORY SYSTEM
SECONDS LIVING RADIOISOTOPES
SODIUM
SODIUM 24
SODIUM ISOTOPES
TISSUES
TRACER TECHNIQUES
UREA