Pulmonary transvascular flux of transferrin

Journal Article · Wed Nov 01 04:00:00 EST 1989 · Journal of Applied Physiology (1985); (USA)

OSTI ID:7244444

Cooper, J A; Malik, A B ^[1]

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1. Albany Medical College of Union Univ., NY (USA)

We compared the pulmonary transvascular fluxes of transferrin and albumin in the intact sheep lung. Anesthetized sheep were prepared with lung lymph fistulas. The vascular blood pool was marked with {sup 99m}Tc-erythrocytes, autologous transferrin was labeled with {sup 113m}In, and albumin was labeled with {sup 125}I. Samples of blood, plasma, lymph, and lung were obtained up to 180 min after tracer infusion. Lymph tissue radioactivities were corrected for the intravascular component and expressed as extravascular-to-plasma concentration ratios. Clearance of transferrin and albumin from the plasma space followed a two-compartment model. The clearance rate constant was 2.1 {plus minus} 0.1 x 10(-3) min for albumin and 2.4 {plus minus} 0.1 x 10(-3) min for transferrin (P less than 0.05). Lymph-to-plasma ratios for albumin and transferrin were not different. However, the extravascular-to-plasma ratio for albumin was greater than transferrin (P less than 0.05). The lymph and lung data were deconvoluted for the plasma input function and fit to a two-compartment model. The results indicate that albumin and transferrin have similar permeabilities across the vascular barrier but have different pulmonary circulation to lymph kinetics because the extravascular volume of distribution of albumin is greater than transferrin.

• OSTI ID: 7244444
• Journal Information: Journal of Applied Physiology (1985); (USA), Journal Name: Journal of Applied Physiology (1985); (USA) Vol. 67:5; ISSN JAPHE; ISSN 8750-7587
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALBUMINS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD-PLASMA CLEARANCE
BODY
BODY FLUIDS
CELL CONSTITUENTS
CELL MEMBRANES
CLEARANCE
DAYS LIVING RADIOISOTOPES
DOMESTIC ANIMALS
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
GLOBULINS
GLOBULINS-BETA
HOURS LIVING RADIOISOTOPES
INDIUM 113
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LUNGS
MAMMALS
MATERIALS
MATHEMATICAL MODELS
MEMBRANE TRANSPORT
MEMBRANES
METALLOPROTEINS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PERMEABILITY
PROTEINS
RADIOISOTOPES
RESPIRATORY SYSTEM
RUMINANTS
SHEEP
STABLE ISOTOPES
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRACER TECHNIQUES
TRANSFERRIN
VERTEBRATES
YEARS LIVING RADIOISOTOPES