Selective killing of T lymphocytes by phototoxic liposomes
Journal Article
·
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
Two-fold specificity in drug delivery obtained through the localized activation of drugs by physical means and the attachment of drugs to proteins that bind to target cells might be used for highly selective cancer chemotherapy or for immunosuppression. Toward this end, a monoclonal antibody against an antigen on the surface of T lymphocytes was covalently attached to liposomes containing a phototoxic drug, pyrene, bound to the lipid bilayer. When unfractionated peripheral blood lymphocytes, or B- and T-cell lines, were irradiated after treatment with these liposomes, T cells were killed while B cells were spared, demonstrating the validity of the approach in a simple in vitro assay.
- Research Organization:
- Columbia Univ., New York, NY
- OSTI ID:
- 7084397
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 1; ISSN PNASA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANTIBODIES
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CONSTITUENTS
CHOLESTEROL
CONNECTIVE TISSUE CELLS
COVALENCE
DNA REPLICATION
FUNCTIONS
HYDROXY COMPOUNDS
IRRADIATION
LEUKOCYTES
LIPOSOMES
LYMPHOCYTES
MATERIALS
MONOCLONAL ANTIBODIES
NUCLEIC ACID REPLICATION
ORGANIC COMPOUNDS
ORGANOIDS
RADIATION EFFECTS
SOMATIC CELLS
STEROIDS
STEROLS
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANTIBODIES
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CONSTITUENTS
CHOLESTEROL
CONNECTIVE TISSUE CELLS
COVALENCE
DNA REPLICATION
FUNCTIONS
HYDROXY COMPOUNDS
IRRADIATION
LEUKOCYTES
LIPOSOMES
LYMPHOCYTES
MATERIALS
MONOCLONAL ANTIBODIES
NUCLEIC ACID REPLICATION
ORGANIC COMPOUNDS
ORGANOIDS
RADIATION EFFECTS
SOMATIC CELLS
STEROIDS
STEROLS