Metabolic fate of inhaled Co aerosols in beagle dogs

Journal Article · Mon Dec 01 04:00:00 EST 1986 · Health Phys.; (United States)

DOI:https://doi.org/10.1097/00004032-198612000-00007· OSTI ID:7082266

Kreyling, W G; Ferron, G A; Haider, B

Lung retention of /sup 57/Co in dogs after the inhalation of physically and chemically uniform particles of Co compounds was similar, indicating little biological variability. The retention of Co oxide particles ranging from 0.3 micron to 2.7 micron geometric diameter, however, depended markedly on their physicochemical parameters. Measuring the retention by a gamma camera, and analyzing excreta and blood samples enabled the distinction of different clearance pathways from the lungs particularly with the use of results of some metabolic studies. Particle dissolution was the predominant clearance pathway. Particle dissolution half-times ranged from 6 to 80 d proportional to the size of the particles. Organ analysis yielded information on the fate of the long-term burden of Co in the lungs and other organs. A fraction less than 10% of the initial lung burden was retained in the lungs of all dogs with a biological half-time of 400 d presumably after being transformed into a nonparticulate state. There were cellular structures in the tracheobronchial tree which accumulated Co significantly. These studies on dogs suggest the dose after human exposure to well-defined Co aerosols can be accurately estimated. Whereas risk assessment after the exposure to undefined aerosols containing radionuclides of Co will mostly be impossible because retention varies widely with the varying physicochemical properties of the aerosol particles.

• Research Organization: Institut fuer Strahlenschutz, Neuherberg, Germany, F.R.
• OSTI ID: 7082266
• Journal Information: Health Phys.; (United States), Journal Name: Health Phys.; (United States) Vol. 6; ISSN HLTPA
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
BODY BURDEN
COBALT 57
COBALT ISOTOPES
COLLOIDS
DAYS LIVING RADIOISOTOPES
DISPERSIONS
DISTRIBUTION
DOGS
ELECTRON CAPTURE RADIOISOTOPES
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPES
LUNGS
MAMMALS
METABOLISM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOACTIVE AEROSOLS
RADIOISOTOPES
RESPIRATORY SYSTEM
RETENTION
SOLS
TISSUE DISTRIBUTION
VERTEBRATES