Retention of monodisperse or polydisperse aluminosilicate particles inhaled by dogs, rats, and mice

Journal Article · Fri Jul 01 00:00:00 EDT 1983 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(83)90258-2· OSTI ID:5602682

Snipes, M B; Boecker, B B; McClellan, R O

This study compared long-term retention of /sup 134/Cs-labeled fused aluminosilicate particles inhaled by three animal species. Dogs, rats, and mice were briefly exposed to 0.7-, 1.5-, or 2.8-micron activity median aerodynamic diameter (AMAD) monodisperse particles or a polydisperse aerosol with 1.5 to 2.0 micron AMAD and geometric standard deviation of 1.5 to 2.0. Tissues and excreta were collected for up to 850 days after exposure to determine retention and clearance patterns of the inhaled particles. Simulation models were developed for each animal species and aerosol. Solubilization was the dominant factor in long-term lung clearance for most of the particles inhaled by dogs; mechanical clearance was dominant in rats and mice. After accounting for solubility, physical clearance from the lung to the gastrointestinal tract and to lung-associated lymph nodes (LALNs) was independent of particle size within the size range investigated. Rats and mice demonstrated a rapid clearance from the pulmonary region, with most of the mechanically cleared particles going to the gastrointestinal tract; significant translocation to the LALNs occurred for only a few days. The dogs cleared deposited particles at a slower rate, with most of the long-term clearance going to LALNs. A small portion of the initial deposit was retained in the upper respiratory tract of all three species. Results from the data for dogs were used to make long-term predictions for chronic inhalation of particles by humans.

• Research Organization: Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico
• OSTI ID: 5602682
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 69:3; ISSN TXAPA
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ALUMINIUM COMPOUNDS
ALUMINIUM SILICATES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MODELS
CESIUM 134
CESIUM ISOTOPES
CLEARANCE
DISTRIBUTION
DOGS
EXCRETION
HOURS LIVING RADIOISOTOPES
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LUNG CLEARANCE
MAMMALS
MICE
NUCLEI
ODD-ODD NUCLEI
OXYGEN COMPOUNDS
PARTICLE SIZE
PARTICLES
PARTICULATES
RADIOISOTOPES
RATS
RODENTS
SILICATES
SILICON COMPOUNDS
SIZE
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES