Clearance, translocation, and excretion of beryllium following acute inhalation of beryllium oxide by beagle dogs

Journal Article · Wed Aug 01 04:00:00 EDT 1990 · Fundamental and Applied Toxicology; (USA)

DOI:https://doi.org/10.1016/0272-0590(90)90050-T· OSTI ID:6318189

Finch, G L; Mewhinney, J A; Hoover, M D; Eidson, A F; Haley, P J; Bice, D E ^[1]

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1. Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM (USA)

Beagle dogs inhaled radiolabeled beryllium oxide (7BeO) particles that were calcined at either 500 or 1000 degrees C, resulting in either high (mean of 50 micrograms/kg body wt) or low (mean of 17 micrograms/kg body wt) initial lung burdens (ILBs) of both preparations of BeO. Levels of beryllium in whole body, tissue, and excreta were measured by external gamma-ray counting. Dogs were euthanized in pairs at 8, 32, 64, and 180 days after exposure to determine beryllium distribution in tissues. Beryllium oxide calcined at 1000 degrees C was retained more tenaciously in the lungs (62% of the ILB retained at 180 days after exposure) than BeO calcined at 500{degree}C (14% of the ILB retained at 180 days after exposure). Most of the beryllium that was cleared from the lungs and not excreted was translocated to the tracheobronchial lymph nodes, skeleton, liver, and blood. More beryllium was translocated to the skeleton and liver at 180 days after inhalation of BeO prepared at 500{degree}C than at 1000{degree}C. The predominant mode of excretion at early times after exposure was through the feces, with urinary excretion assuming predominance at later times. These data are important for interpreting the toxic effects of beryllium in the exposed dogs. Furthermore, because little is known concerning the retention and clearance of inhaled beryllium in man, these results provide information that may be used to understand the disposition of beryllium in accidentally exposed humans.

• OSTI ID: 6318189
• Journal Information: Fundamental and Applied Toxicology; (USA), Journal Name: Fundamental and Applied Toxicology; (USA) Vol. 15:2; ISSN 0272-0590; ISSN FAATD
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ALKALINE EARTH METALS
ANIMALS
BEAGLES
BERYLLIUM
BODY
BODY BURDEN
CLEARANCE
DISTRIBUTION
DOGS
ELEMENTS
EXCRETION
INHALATION
INTAKE
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LUNG CLEARANCE
LUNGS
MAMMALS
METABOLISM
METALS
ORGANS
RADIOISOTOPES
RESPIRATORY SYSTEM
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VERTEBRATES