Pharmacokinetics of ethoxyethanol in humans

Technical Report · Mon Feb 01 04:00:00 EST 1988

OSTI ID:7080618

Hattis, D; Berg, R

Pharmacokinetic models were developed of the uptake of ethoxyethanol (EE), metabolism of EE via ethoxyacetaldehyde to ethoxyacetic acid (EAA), and urinary excretion of EAA. The performance of these models was tested with data on EE exposure, and preshift and postshift urinary EAA excretion/gram creatinine in a group of 36 painters studied over several successive days. The less simple model resulted in a peak of urinary EAA just under 3 hours after the end of exposure and had a half time for urinary EAA excretion of 33 hours. About 42% of retained EE was metabolized via the aldehyde-dehydrogenase pathway. The method incorporated plausible features used in full physiologically based pharmacokinetic models, fit to the urinary EAA excretion data as well as any other and better than some models, demonstrated a later peak of EAA urinary excretion which is more in keeping with earlier studies, and performed slightly better in reconciling moles EE absorbed as calculated by other methods.

• Research Organization: Massachusetts Inst. of Tech., Cambridge (USA). Center for Technology, Policy and Industrial Development
• OSTI ID: 7080618
• Report Number(s): PB-88-221528/XAB; CTPID-88-1
• Country of Publication: United States
• Language: English

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BIOLOGICAL MATERIALS
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PAINTS
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